Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence


For those of us with blood glucose control difficulties, this could be a great addition.

And a great word in that second article: splanchnic – of or relating to the viscera.



stimulates protein synthesis in skeletal muscle through the mammalian target of rapamycin signaling pathway

There seem to be many papers on L-citrulline effects on muscular/vascular health including (via

L-citrulline, a precursor of nitric oxide, has been shown to enhance vascular function and muscle protein synthesis, particularly when combined with exercise training in older adults (Figueroa 2020).

Here is the full review article
[Sci-Hub | l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults. Exercise and Sport Sciences Reviews, 48(3), 133–139 | 10.1249/jes.0000000000000223]

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My view, take L-citrulline and L-arginine supplementation, eat arugula*{has a high nitrate content] and take tadalafil 2.5mg dissolve under the tongue.{yes I allow to dissolve under the tongue]

Been doing just arugula, will be adding
L-citrulline and L-arginine supplementation

The tadalafil “kick starts” NOS.

Noninvasive assessment of endothelial function can be measured using an EndoPAT device.

*…The European Food Safety Authority (EFSA) has declared that arugula is an essential source of nitrate, with the highest nitrate concentration up to 6400 ppm"…