I think it was in a podcast by Peter Attia where I heard that the compounded forms of Rapamycin were not absorbed as well as the version from the drug company. Anyone familar with this concern?
Thx
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Discussed here New Peter Attia interview w/Matt Kaeberlein, inferior bioavailability of encapsulated rapa
And here Bioavailability of Rapamycin From Compounding Pharmacy
If you’re still interested… I confirmed Peter Attia’s remarks by comparing peak levels of conventional Rapa (about 1.6-1.8 ng/mL) to my compounded form (zip!). My pharmacy (shout out to Peninsula Pharmacy in Long Beach, WA) supplied me an “Acid Resistant” form to test… also zip. But I was pretty sure it was having some effect so I asked them to double my usual dose, from 6 mg to 12 mg, keeping the AR formulation. Peak level 2.6! So THANK you Peter Attia for publicizing the issue and to my creative pharmacist for coming up with an effective tweak!
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