“Mesenchymal stem cells (MSC) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease conditions, including tissue repair, inflammation, autoimmunity and organ transplantation. Importantly, systemically-infused MSC selectively home to primary and metastatic tumors, though the molecular mechanisms of tumor tropism of MSC remain incompletely understood. We have exploited the active and selective MSC homing to cancer microenvironments to develop a rapid and selective blood test for the presence of cancer. Here we present the concept of using transplanted MSC as the basis for a simple cancer blood test.Mesenchymal stem cells (MSC) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease conditions, including tissue repair, inflammation, autoimmunity and organ transplantation. Importantly, systemically-infused MSC selectively home to primary and metastatic tumors, though the molecular mechanisms of tumor tropism of MSC remain incompletely understood. We have exploited the active and selective MSC homing to cancer microenvironments to develop a rapid and selective blood test for the presence of cancer. Here we present the concept of using transplanted MSC as the basis for a simple cancer blood test.”
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)33836-9