Everyone saw that it’s an injection, I assume. Thats going to make it harder (impossible?) to get from low cost offshore sources (if it requires refrigeration).
From the original writeup:
But Cook, who also took the combination, says there was an effect. “And I have to tell you, it was the most surprising thing that ever happened to me,” he says. After taking the weekly injections, he experienced a sense of mental clarity that lasted for a day, and then several days. The other subjects, he says, reported a sense of well-being, as well as old aches and pains that evaporated.
They won’t release what it is. They intend to see if they can get FDA clearance for it. But, if they’re testing it at clinics then I can’t imagine that it’s too hard to get hold of. The only thing is that there’s no way of knowing what the price point is.
After watching hucksters like Sinclair get insanely rich off of fraudulent longevity claims, after a respectable scientific life career that brought acclaim but not much moolah, it’s time to fund retirement by cashing in that reputation, the line forms here, roll up your sleeves and open your wallet, the procedure on the arm will be barely a pinch, do not ask what’s in that shot as it might interfere with the walletectomy that’ll extract a blood curdling scream, we shall live for a long, loong, looong time, loooooo…and if not, dead people are not able to object, there will be no return of funds, no consequence to anyone, or instead take that wallet and get yourself the vacation you always dreamed of, because as you lie dying what will run through your mind the shot in the arm - but they promised! - or that beautiful vacation with a loved one on a sandy beach? Inquiring minds want to know… what’s behind that sideways photo, that glance, allure, promise, the gaze of a cobra, or…
I’m not sure I understand the implication. They were asked about the work and mentioned that they were taking the intervention themselves. That doesn’t constitute evidence that it works, obviously, but neither does mentioning it strike me as particularly suspicious.
The interesting question is whether the underlying biology is sound and whether the data eventually support the claims.
I think that it shows they have some confidence in their new drug combination in terms of safety at least… so I’m not surprised they are doing this, and telling people.
Richard Miller is in a different situation; he works for the government and the NIA doesn’t want to be seen to be promoting drugs off-label that haven’t been tested in rigorous studies (oriented towards longevity). I can understand why Richard Miller won’t say what he’s taken or not taken.
But for Irina Conboy who is no longer associated with UC Berkeley (only her company) she doesn’t have to worry about academic or govt. constraints that Richard Miller would.
In the Matt Kaeberlein interview on 30th July Irina Conboy claimed to have invented a new aging clock that doesnt have all the drawbacks of the existing eipigenetic clocks. This sounded much more convincing. You would have thought they would have been talking about the results of the 2 drug combo on this new aging clock by now? But i guess maybe “we tested a drug combo we developed using a clock we also developed” wouldn’t seem that convincing and it has only been a month.
Too bad the Conboys are chasing money. Their work on neutral blood exchange, showing the positive effects of replacing a portion of old plasma with saline, seemed very promising. Needed follow-up to assess dosing and frequency as it could very be that periodic FREE plasma donation (about 25% of plasma removed) could have some of these same positive effects as NBE.
It’s bizarre. Share with family and friends? Share what? There’s no published research, no trials. I guess we are offered to take their word for it. Cannot wait to learn more. Intriguing for sure.
Generally when you launch a new product you present the most compelling data you can pull together. If this is the most compelling data… It makes you go hmmmm…
One of the slides declares, “People care about improvements they can FEEL,” placing the key word in all caps. As body builders say, in a mocking tone, “It’s all about the feelz.”
Oxytocin was my first guess. But they said it wasn’t in the combination, and it has a very short half-life. I did some research and there’s a synthetic called Carbetocin, which hits the same mechanism, but that’s not a generic. The other thing is that the life extension only worked in male mice with the oxytocin combination and didn’t work for females. I guess we’re all just going to have to wait.
