I thought this was quite good much that he is not a fan of Rapamycin, but I agree with his point on this (which is why I take it less frequently than pretty well everyone).
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- Creatine monohydrate
- Vitamin E
- Alpha lipoic acid
- COq10
30:24 to 31:11
Cocktail lowers lactate. Higher lactate indicates mitochondria not working. 31:42
Ubiquinol versus ubiquinone. Ubiquinone is COQ10. But in the blood, 99% gets converted anyway. 37:43.
They used ubiquinone in all their studies 38:01.
We used alpha tocopherol - 39:39.
About Urolithin A
And when you look at the outcome metrics in the studies, they’re not really that impressive or consistent across the various studies. So, again, there is no magic bullet, I would caution people against a single entity. 52:45
Sarcopenia
Best way to prevent sarcopenia is a combination of endurance, plus resistance exercise. 56:27.
Vitamin D, calcium, fish oil, whey protein, creatine - 57:15. Given to older adults, which showed increases in muscle mass, even before exercise. Combination is superior to collagen peptides - 58:02
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Galantamine and Metformin for sarcopenia is showing good results. Galantamine nukes ROS.
https://www.sciencedirect.com/science/article/pii/S0969996119303705
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@JuanDaw Do you recall if Dr Tarnopolsky did his test on diseased individuals or healthy (and trained) people when testing for lower lactate with his supplement cocktail? I wonder about the timing of the supplementation of antioxidants around training (offset some training benefit?).
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30:12
So in 2007, we took we took this approach in patients with genetic mitochondrial disease, and whenever I say that, really it should apply to aging 'cause at the cell level they’re the same.
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I think he is right that mitochondrial damage is at the core of aging (particularly damage to the mtDNA and particularly damage that results in a reduction in the mitochondrial membrane potential). The other core is senescence.
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Several peptides, especially MOTS-c and SS-31, should be at least as good as a mitochondrial cocktail. Or maybe both are twice as good as either.
Add Ergothioneine (EGT):
EGT is highly beneficial to mitochondrial health. It accumulates in mitochondria and improves their function in several ways: 1. EGT enhances mitochondrial respiration and oxygen consumption, indicating increased energy production. 2. It protects mitochondria from oxidative damage by acting as a potent antioxidant, preventing mtDNA damage and maintaining membrane potential. 3. EGT activates the enzyme 3-mercaptopyruvate sulfurtransferase (MPST) in mitochondria, which boosts mitochondrial respiration. 4. It improves aerobic performance and exercise endurance. In mice, EGT supplementation increased time-to-exhaustion by 41.22%. 5. EGT accumulates in muscle mitochondria during exercise, suggesting a role in exercise-induced mitochondrial. 6. it reduces markers of metabolic stress, inflammation, and oxidative damage in muscles after exercise.
Would be nice if you provided a link to the source material.
Could be the study below.
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST
Ergothioneine (EGT) is a diet-derived, atypical amino acid that accumulates to high levels in human tissues. Reduced EGT levels have been linked to age-related disorders, including neurodegenerative and cardiovascular diseases, while EGT supplementation is protective in a broad range of disease and aging models in mice. Despite these promising data, the direct and physiologically relevant molecular target of EGT has remained elusive. Here we use a systematic approach to identify how mitochondria remodel their metabolome in response to exercise training. From this data, we find that EGT accumulates in muscle mitochondria upon exercise training. Proteome-wide thermal stability studies identify 3-mercaptopyruvate sulfurtransferase (MPST) as a direct molecular target of EGT; EGT binds to and activates MPST, thereby boosting mitochondrial respiration and exercise training performance in mice. Together, these data identify the first physiologically relevant EGT target and establish the EGT-MPST axis as a molecular mechanism for regulating mitochondrial function and exercise performance.
https://www.biorxiv.org/content/10.1101/2024.04.10.588849v1.full
Thank you.
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Have you upped your galantamine dose to 8mg?
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No I haven’t. Is this something you’d suggest? (Still on 4mg AM)
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Mitochondria also are living organisms themselves and have more mechanisms for dividing/diluting out “bad/damaged mitochondria” [ESP in younger individuals] than other kinds of cells [the opposite can also happen]
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I am not sure. I see others on the forum increasing or thinking of increasing their dosage. I have been on 4 mg for close to 2 months and l believe l am seeing benefits. I take mine in the a.m. as well but l am curious if an additional 4 mg at night might be of benefit.
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Good point. I’m going to take the plunge. It’s 11:23 PM U.K. time. Going to take 4mg tonight. Wish me luck.
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didn’t mean to peer pressure you into it! Please let me know if feel any additional positive benefits.
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All good. No benefits to report. Had a bad sleep but its because of other known reasons. Will keep it up for a week and note any benefits.
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