There is supposed to be 7-tablet versions available (rather than 30). I haven’t been able to find a supplier yet. This would make storage / preventing waste a little easier…
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Are his prices for real? $4us for 100x 5mg tadalafil? That’s crazy!
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Yes, and on my first order from another vendor, the vendor threw in an extra 100 as a bonus.
A recent quote from Maulik:
Please find the quote as below
Tadalafil 5 mg - 15$ / 300 tablets
Dutasteride 0.5 mg - 15$ / 300 tablets
Shipping to USA - 20$
Total - 50$
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Are they legit? This price almost seems too good to be true.
They are legit. I’ve ordered from them as well a couple of times. Maulik is my source for Galantamine.
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Hell yea man. This changes everything. I made a small order to test it out.
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This earlier posted Open Access paper is now available:
The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy
In this paper we show that inhibition of the MEK/ERK cascade, by Tram, diminishes at least five enzymes involved in hepatic de novo lipogenesis (DNL), and does so via a non-transcriptional process. We show that Tram treatment enhances CMA in mouse liver and cultured cells, and that augmented CMA is sufficient to explain transcription-independent downregulation of DNL enzymes. Levels of these DNL enzymes are also downregulated in young adult mice by Aca, Cana, and the CR diet. CMA-mediated alteration in protein levels may be an important non-transcriptional regulator shared by several models of slower aging in mice, and may play a role in lifespan extension induced by Tram on its own or in combination with Rapa.
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A quick look on IndiaMart shows prices have come down considerably… anyone trying this?
No reports yet. See here for the issues: A Combination of Rapamycin and Trametinib Extended Maximum Lifespan by up to 35% - #154 by RapAdmin
My guess is that a week outside the refrigerator just reduces efficacy, a .5mg dose becomes only .25mg or something like that
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That may be true, but most shipments from India (in my experience) take 2 to 3 weeks, and we really have no clue how well stored the product was in India (famous for its 100 degree + weather during many months of the year)…
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Research on Trametinib for stomach and esophageal cancer is proceeding at what seems like a snails pace. It is likely to be quite effective for treating pre cancerous lesions, but it is not considered ethical to give cancer drugs to people who do not have cancer yet. Of course waiting for an adenocarcinoma to treat may be too late. Vanderbilt University is taking the lead on this and has a lot of good info.
Apparently the side effect risks of Trametinib are taken very seriously—even for only a two week course.
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Just a reminder for anyone planning to order Trametinib from India:
I am doing my first order of 30 tables of 0.5mg Trametinib (Generic Meqsel by Novartis) from India, shipped from New Delhi this Jan to take advantage of the coldest month for shipping from India. I got one quote of $910 including shipping and 50% customs duty prepaid to India Post, from a New Delhi Indiamart Merchant (BS Lifecare Pharma). Waiting for a couple other quotes.
Update:
Another merchant (Sipmax Pharma) quoted me $690 including shipping, and uses a customs declaration for health supplements without the customs surcharge, but says he has several US customers in recent months that got their shipments without any customs issues. They also include a cooler pack and insulated shipping box since they ship from Mumbai, which is warmer then New Delhi (above the 86F limit on some days in Jan). I have placed an order with them.
Another merchant (A Square Pharmaceuticals, New Delhi) quoted Rs 53,000 for the Meqsel 30x0.5mg and Rs 8,000 for shipping and customs, which works out to a total of Rs 61,000 or $677 at current exchange rates. I am thinking of placing a backup order with them: They also use a cooler pack with insulated shipping box, and they believe the medicine should always be kept at 8C/47F or lower and they store their stock in a fridge.
Update on 1-22-26:
Sipmax Pharma shipped on Jan-13 and it was delivered in San Diego on Jan-21 and the cooler packs were still cool.
The other merchant (A Square Pharmaceuticals) backed out of using India Post EMS after noticing the refrigeration requirement: They insisted it could only be shipped with cooler pack using FEDEX 3 day which would require a doctor’s RX and Lab Reports (???) and full payment of 50% customs duty. I declined since I know exposure to higher temps up to 86F for up to 30 days is OK, but give them credit for being conscientious about not damaging this expensive medicine.
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Other natural supplements much less potent have similar pathways on MEK/ERK: modulators; Myricetin, quercetin, EGCG, rocaglamides,
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I just took my first dose of Trametinib 0.5mg that I received from Indiamart (see my previous post), and will repeat every 3 weeks, based on the protocol developed above in this thread by cl-user.
My wife is holding off for a couple months to see if I develop any serious side effects …
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Smart. Does she stand to inherit a lot🤣?
But seriously - please report back often, there are many here who are watching this combo.
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How many days prior to starting was your previous blood test, and what measures are you tracking? Do you have any specific strategy on things to measure in case things are going the wrong direction, or things to measure if things are going well?
Are you dosing rapamycin at the same day/time? What is your current rapamycin protocol? Please don’t make any other changes during your trial (so as to isolate the variables a bit), and let us know how you feel.
My last comprehensive blood panel (+ Jinfinity AgingSOS panel) was 3 months ago on 10-21-25, but I will be taking a smaller panel (LEF basic hormones + CBC) next Wednesday. Will keep monitoring CBC monthly to monitor any liver or kidney damage.
I am on 10mg Rapamycin weekly (Mondays) for over a year now. I am hoping this is the improved cancer prevention protocol (vs just Rapamycin).
Will update any symptom changes or labs.
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Tangentially related: I was diagnosed with intestinal metaplasia (a pre cancerous stomach lesion) four years ago. Trametinib has been shown to cure intestinal metaplasia in several animal studies by MEK inhibition, but there may never be a human trial. I read somewhere that quercetin is a mild MEK inhibitor, so I had been taking quercetin along with weekly Rapa, taurine, vitamin c, along with plenty of fruits and vegetables. I had a follow up endoscopy a month ago, and none of the nine tissue samples showed an intestinal metaplasia or any other pre-cancerous condition. Cured? Biopsies missed it? And if cured then cured by which thing? In any event, MEK inhibitors may be a potent tool.
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