Yes - data like this suggests its unlikely anyone is going to die by overdosing on rapamycin…
But… this was with lab mice, in a sterile environment. Unfortunately we don’t live in a sterile environment so we probably have more risk from immune suppression of rapamycin at high doses for long periods of time.
Wait I thought the dose conversion factor must be applied. Its known that larger species animals dont take a weight proportional dose as much smaller ones.
376/ conversion rate of 12.3 from mice to human thats only 30 mg… you would in theory exceed it with just 20 mg + grapefruit.
Ah yes - using this reference table mentioned here, but to also be fair - in that study at 8mg/kg they were dosing the mice daily over a period of months (not weekly like most people taking rapamycin here)… so we still aren’t comparing apples to apples yet.
From this document:
DAILY. that’s a MASSIVE number. What’s the dosage that immunosuppressive patients take?
“376/ conversion rate of 12.3 from mice to human thats only 30 mg… you would in theory exceed it with just 20 mg + grapefruit.”
Where did you get that?
I’ve added the human dose equivalent calculation table above so you can see the reference.
Typically 2mg to 5mg per day.
Thats a important mention yea , so for humans we would either need to equate 30 mg a day or a higher number per week.
One other thing is if we look at the graph on Kaeberlein study the weight begins to strongly drop once treatment started, and 3 months transiently may have much a higher optimal dosage vs lifelong. Since it can somewhat compensate for both before and after treatment while being buffered from potential side effect issues.