Whatever psilocybin does, this is much shorter and more powerful
Nick cammarata said it’s the perfect treatment if you just figure out how to reduce the nightmare probability
Plus LEGAL IN CANADA
https://x.com/0xQuasark/status/2013701597268783385?s=20
Full Open Access Paper: Complex slow waves in the human brain under 5-MeO-DMT
The “God Molecule” Paradox: 5-MeO-DMT Freezes Brain Waves to Deconstruct Reality
Institution: University College London (UCL), UK Journal: Cell Reports (August 2025)
Overview: For the first time, researchers have captured the neural signature of the “void”—the total annihilation of self and space reported by users of 5-MeO-DMT. Unlike classical psychedelics (LSD, psilocybin), which typically increase neural entropy (chaos) and scramble communication, this study reveals a startling paradox: 5-MeO-DMT pushes the brain into a state of hyper-stability.
Using high-density EEG on 29 subjects inhaling 12mg of synthetic 5-MeO-DMT, the team discovered that the drug effectively “breaks” the traveling waves of electrical activity that normally sweep across the cortex to coordinate perception. Instead of a fluid river of information, the brain’s activity fractures into viscous, non-recurring eddies that cannot travel forward or backward. The “energy landscape” of the brain deepens, trapping neural activity in a low-dimensional “stiff” state.
This suggests that the subjective experience of “oneness” or “nothingness” isn’t an explosion of connectivity, but a collapse of the spatiotemporal scaffolding that constructs our reality.
The researchers discovered that 5-MeO-DMT generates high-amplitude “slow waves” (usually a sign of deep sleep or coma) while the subject remains fully awake. However, unlike the synchronized slow waves of sleep, these waves are “viscous,” incoherent, and unable to propagate globally. This effectively fragments the brain’s communication network, preventing the integration of information required to sustain the “self.”
Source:
While the paper focuses on EEG dynamics, the findings unlock significant implications for longevity, specifically regarding allostatic load reduction and neural plasticity.
Warning: 5-MeO-DMT is extremely potent. The following is based on clinical parameters, not medical advice.
1. Is “deconstructed consciousness” just a fancy word for blacking out? No. The study proves you are physiologicallyawake (muscles active, eyes can open) and phenomenologically conscious (aware of “being”), but the content of consciousness (vision, self, time) is deleted. It’s like formatting a hard drive vs. turning off the computer.
2. Does this actually extend lifespan? No direct evidence exists. However, if it reduces chronic cortisol and treats depression (which shortens telomeres), it acts as a geroprotector proxy. The massive release of acute stress hormones during the trip is a hormetic stressor—beneficial only if recovery is adequate.
3. How does this compare to Psilocybin for longevity? Psilocybin induces hyper-connectivity (“entropic brain”). 5-MeO-DMT induces disconnection (“void”). 5-MeO is better for “breaking” rigid patterns (addiction, OCD) rapidly; Psilocybin is better for “rewiring” emotional insights over hours.
4. Can I stack this with Rapamycin? Likely yes. Rapamycin (mTOR inhibitor) has no known interaction with acute serotonergic agonists. However, avoid stacking with Lithium (seizure risk) or SSRIs/MAOIs (Serotonin Syndrome).
5. What is the “Viscosity” finding telling us about brain aging? Brain aging is often characterized by “stiffness” or loss of dynamic flexibility. Paradoxically, 5-MeO increases viscosity acutely to force the brain into a simple state, potentially allowing it to “reboot” into a more flexible state post-trip. This is the “shake the snowglobe” effect.
6. Is the “Toad” venom better than synthetic? Scientifically, no. Toad venom (Incilius alvarius) contains 5-MeO-DMT plus bufotenin and other toxins (cardiotoxic). Synthetic 12mg is cleaner, more precise, and avoids animal cruelty issues. The study used synthetic.
7. Why 12mg? 12mg is a high dose designed to guarantee “breakthrough.” Lower doses (3-6mg) can induce anxiety without the release of ego dissolution, often resulting in a “panic” state rather than a “void” state.
8. Is there a “Hangover”? Rarely. Most users report an “afterglow” lasting days to weeks. However, “reactivations” (spontaneous brief flashbacks of the sensation) can occur in the week following high doses.
9. What if I have high blood pressure? Do not use. The acute spike in BP is significant. If you are managing hypertension, this is a contraindication until stable.
10. What is the single most actionable takeaway? If you are a biohacker looking for a “neural defrag” to combat executive burnout or rigid thinking, 5-MeO-DMT offers the highest time-efficiency. However, it requires a sitter and cardiac safety, unlike sub-perceptual microdosing. Treatment should be viewed as a high-intensity interval training (HIIT) session for the brain.
The psychedelic 5-MeO-DMT seemed to induce similar patterns of brain activity in a lama - a revered spiritual teacher in Tibetan Buddhism - as meditation, advancing our understanding of the drug’s neurological effects
A master meditator has spent 15 years learning to quiet his sense of self – and brain scans suggest he achieved a similarly altered state with a powerful psychedelic.
“There seems to be, with that low dose [of the psychedelic], a significant overlap in terms of brain activity with what’s happening in non-dual meditation state [a style of practice that makes no distinction between the self and the rest of the world],” says Christopher Timmermann at University College London.
The study was also made up of a single, experienced meditator, so the results may not apply more broadly, particularly as brain-activity related studies can be unreliable. What’s more, blinding participants is notoriously difficult in psychedelic research, because the side effects of hallucinogenic drugs usually alert people to when they have taken them, as opposed to a placebo, although the lama didn’t report such effects.
Read the full story: Psychedelic causes similar brain state to meditation (New Scientist)
