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4 factors:
Lower APOB,
Lower Bloodpressure,
Lower weight,
Exercise (optional)
And, a good in-depth “Grand Rounds” talk by Thomas Dayspring on the causal factors behind atherosclerosis:
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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcp.30887
Metformin protects against atherosclerosis.
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Glisodin may help to reverse atherosclerosis. From LEF: “Remarkably, the physicians found that two years of supplementation with GliSODin® actually reversed the buildup of atherosclerotic plaque in the carotid arteries, as determined by ultrasound measurements of carotid intima-media thickness.”
More info:
GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging
M Cloarec et al. Eur Ann Allergy Clin Immunol. 2007 Feb.
Abstract
Prevention of cardiovascular disease should target high-risk subjects based on genetic/familial factors, blood chemistry, blood pressure, body mass index (BMI), and a history of/or current cigarette smoking. We selected active adults (n=76) aged 30-60 and investigated these risk factors, in order to recommend preventive measures. Another interesting variable is the preclinical status or atheroma of the arterial (carotid) wall or lumen. We also investigated the presence of oxidative stress in, and the anti-oxidant status of these subjects. We studied the anti-oxidative efficacy of superoxide dismutase (SOD) and variations of malondialdehyde (MDA). Supplementation with GliSODin, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured uby ultrasonography-B. We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease.
Additional information from a citing study:
”A research study on individuals at risk for developing atherosclerosis demonstrated a striking difference between the control and the protected SOD–supplemented group when examining carotid thickness. Individuals receiving SOD–gliadin daily (500 U SOD activity) or placebo for a period of 2 y were subjected to B-scan ultrasonography to measure the intima media thickness (IMT), a standard detection method for atherosclerotic lesions. Decreased carotid IMT measurements were seen in patients after 365 d of treatment with SOD–gliadin. Moreover, the supplemented group registered an increase in SOD and CAT levels in the blood compared with the placebo group. Additionally, lipid peroxidation, used as a measurement of oxidative stress, was reduced after SOD–gliadin intake. Together, these data suggest a potential role for SOD–gliadin supplementation in the prevention of atherosclerotic lesions, possibly through its general antioxidant action.”
Reference
Romao S. Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination.Nutrition. 2015 Mar;31(3):430-6. doi: 10.1016/j.nut.2014.10.006. Epub 2014 Nov 5. Erratum in: Nutrition. 2015 Sep;31(9):1187. PMID: 25701330.
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