3 undisclosed drugs successful in NIA ITP -place your bets

#1

There are 3 unrevealed medications which increase life span (31:09 - 31:13)

Here 2022 new supported interventions
Alpha-ketoglutarate (AKG)
Atorvastatin + Telmisartan
Pioglitazone
Methotrexate
Mifepristone

Place your bets

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#2

Earlier findings here:

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From: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions

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#3

I predict:

  • Atorvastatin + Telmisartan: We’ve seen a lot of positive data about Telmisartan already for various metabolic effects, but no lifespan data. I see some moderate promising lifespan data on some different statins in various species in DrugAge
  • Pioglitazone: Glucose metabolism modulation is a known way to increase longevity somewhat. I can’t find lifespan data on it, but it seems like a good bet.
  • Mifepristone is interesting and showed fairly promising effects in female flies 15%-67%. No data in males. Given its antiprogestogen effects I could see it having a significant difference between female and male mice.

The other 2:

  • Methotrexate: Mice are prone to cancer so this could increase their lifespan for this reason, and yet I don’t see good results in previous lifespan studies. One decreased lifespan, the other increased by 7%
  • AKG already didn’t really do anything in a previous study on mice despite promising data in worms. On DrugAge I see a max of 6% increase.

My initial feeling with these three was Methotrexate due to the cancer connection but I’m leaning more towards Mifepristone after looking further into it.

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#4

Probably not Atorvastatin + Telmisartan since these are mice who typically don’t die of heart problems. I believe this combination is by far the best in humans from that list, but probably won’t have a large effect in the ITP.

Guessing AKG is the other one that didn’t work since the previous higher dose didn’t

Pioglitazone is an obvious choice since the other drug in that class showed benefits in mice. The other two must have as well by process of elimination.

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#5

I’ve been pushing pioglitazone for a while now. So that. If I need to pick three, off the top of my head methotrexate and mifepristone. To be honest I didn’t expect that many hits though.