I’m still alive as well lol.
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I tried again yesterday with a very small dose, 0.3mg (measured on a very expensive scale). No noticeable effect. I’m planning to titrate up over the next few weeks.
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There will be an update soon with the lifespan test. Sorry about the wait!
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Study is complete! Original post updated with results and the next step!
@John_Hemming @Joseph @katiii @medaura @KiwiGuy @desertshores @adssx @A_User @Krister_Kauppi @Paul_2.0
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Thank you for organising this. It is useful to have what in a limited way are negative results. It does mean in terms of indoles that IPAM would not be currently at the top of my list for personal experimentation even though I am not a massive fan of worm experiments. However, this is good basic science giving us further information about the molecule. I think you are right to try higher doses.
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No problem John. I’m still hopeful. The significantly higher doses should give us an indication if this is worth pursuing further.
A big shoutout to Ora for facilitating the next study so quickly.
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That’s true, but sadly the worm is not that good for modelling mammalian lifespan.
Too bad it failed! I would be surprised if higher doses work. I’m also disappointed that Ora still hasn’t sent me results from experiments sponsored as far as April 2024…
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Email them and find out what is going on.
I did so. I also had a call with Ben last month. Wait and see…
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Thanks very much for organising this - very interesting! First time I’ve been involved in helping sponsor longevity related research…. 
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This is my first time doing something like this as well. It’s very exciting to feel like we’re contributing something instead of just being passive observers hoping something will happen.
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I intend putting the results in a poster for BSRA 2025 (along with lots of other things). I am happy to agree the associated words with people if they wish. There won’t be many words on this. Although the poster is A0 I want to get a lot in it.
That sounds great. Hopefully the higher dose results are out before this event starts.
The event is in September, but the poster will be physically printed on paper and then laminated. The poster with extended text will be published on https://citrate.science
Hence the deadline for being in the paper poster is probably mid August. I can update the poster on citrate.science at any time.
I will put the draft there at some point, but at the moment it is too untidy to go anywhere.
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I wouldn’t be surprised if the higher doses work. Clearly the highest dose tried was the lowest minimum dose to see any sort of effect so anything tested should be above that dosage to rule out longevity effects. It’s possible that higher doses will just yield bigger worms of the same lifespan or even worse but it’s also possible it will swing in the other direction. Seems smart to continue the experiment.
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A little IPAM experiment I’m doing on myself:
I purchased 1g of IPAM and dissolved some into a tiny bit of moisturizer. I’ve been putting a little on my hand at night before bed.
This isn’t a great control, but I made a 2nd cream in the same moisturizer base that I added 3g of rapamycin and a little melatonin. I’ve been putting it on my other hand.
IPAM treated hand looks a bit smoother.
I took before photos. I’ll take after once I finish up the IPAM cream.
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IPAM basically is a recyclable electron and proton carrier, this is its secret.
You can see it as the non peptide brother of SS-31, (with all advantages of non being a peptide, but this is another story…)
Initially I tried solution pglchem, 1-2-4-8 milligrams per day, for a week.
PEG/PG is toxic then I ordered powder pglchem.
I tried up to 0.5grams oral, the taste was bitter to acid, something like soap.
I started at 50mg doubling each day, at 5th day i had to stop at 0.5g, due to upper stomach burn.
Indeed IPAM is categorized as irritant chem when swallowed
First, for sure pglchem quality is poor.
Second, for sure it trigger hormesis, and i believe the best safe dosage for us is 20-40mg not more.
Third, i noticed some good on first low doses in solution, effects was less heaviness from life, I suffer chronic insomnia, so I can feel better when something help or no mitochondria, which insomnia fragments.
I want give a second chance from a better source.
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Thanks for the experience report. If you do find a better source that sells to the public please share it here.
