I ordered 1g for myself and I have been taking it occasionally. Hard to say what it is doing as I use a variety of supplements, medications and devices for longevity and wellness. It might have a sort of nootropic effect? No negative effects that I have noticed.
I’ve been researching how the human body endogenously produces IPAM and have been implementing this. I feel good on this protocol, which is mostly focused on nitric oxide and gut microbiotia optimization. As I learn more and truly figure this out I will post the protocol.
The lifespan study is underway currently, the moment I am notified of any updates I will make a post.
I tried again yesterday with a very small dose, 0.3mg (measured on a very expensive scale). No noticeable effect. I’m planning to titrate up over the next few weeks.
Thank you for organising this. It is useful to have what in a limited way are negative results. It does mean in terms of indoles that IPAM would not be currently at the top of my list for personal experimentation even though I am not a massive fan of worm experiments. However, this is good basic science giving us further information about the molecule. I think you are right to try higher doses.
Too bad it failed! I would be surprised if higher doses work. I’m also disappointed that Ora still hasn’t sent me results from experiments sponsored as far as April 2024…
This is my first time doing something like this as well. It’s very exciting to feel like we’re contributing something instead of just being passive observers hoping something will happen.
I intend putting the results in a poster for BSRA 2025 (along with lots of other things). I am happy to agree the associated words with people if they wish. There won’t be many words on this. Although the poster is A0 I want to get a lot in it.
The event is in September, but the poster will be physically printed on paper and then laminated. The poster with extended text will be published on https://citrate.science
Hence the deadline for being in the paper poster is probably mid August. I can update the poster on citrate.science at any time.
I will put the draft there at some point, but at the moment it is too untidy to go anywhere.
I wouldn’t be surprised if the higher doses work. Clearly the highest dose tried was the lowest minimum dose to see any sort of effect so anything tested should be above that dosage to rule out longevity effects. It’s possible that higher doses will just yield bigger worms of the same lifespan or even worse but it’s also possible it will swing in the other direction. Seems smart to continue the experiment.
A little IPAM experiment I’m doing on myself:
I purchased 1g of IPAM and dissolved some into a tiny bit of moisturizer. I’ve been putting a little on my hand at night before bed.
This isn’t a great control, but I made a 2nd cream in the same moisturizer base that I added 3g of rapamycin and a little melatonin. I’ve been putting it on my other hand.
IPAM treated hand looks a bit smoother.
I took before photos. I’ll take after once I finish up the IPAM cream.
IPAM basically is a recyclable electron and proton carrier, this is its secret.
You can see it as the non peptide brother of SS-31, (with all advantages of non being a peptide, but this is another story…)
Initially I tried solution pglchem, 1-2-4-8 milligrams per day, for a week.
PEG/PG is toxic then I ordered powder pglchem.
I tried up to 0.5grams oral, the taste was bitter to acid, something like soap.
I started at 50mg doubling each day, at 5th day i had to stop at 0.5g, due to upper stomach burn.
Indeed IPAM is categorized as irritant chem when swallowed
Second, for sure it trigger hormesis, and i believe the best safe dosage for us is 20-40mg not more.
Third, i noticed some good on first low doses in solution, effects was less heaviness from life, I suffer chronic insomnia, so I can feel better when something help or no mitochondria, which insomnia fragments.
