Nice. Keep us updated on the ones you paid for. What ones did you do?
I think I already posted in Ora Biomedical Million Molecule Challenge Results (including those waiting for results). I post whenever I have new results.
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“The 10% fee is applied to all orders and helps cover processing, handling, storage of drug, licensing fees, and taxes.”
They should quote a price including the “fee” then.
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Agreed. I paid the 10% also… if I hadn’t already committed to chipping in $100, I would’ve reduced or cancelled my donation altogether. They probably lose a few people who’d otherwise be donating when they introduce this 10% fee. It’d be MUCH better just to incorporate it into the price upfront!
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When I donated to
Rapamycin Longevity Labs 601 mTOR inhibitor project! Crowdfunding Project Looks for a “Better Rapamycin”
Around the same time - there was no 10% fee there…
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When I get more information from Ora I will make a post here. I will likely make a new post once the results are in.
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My goodies have arrived but now I’m getting a bit gun shy. The jar of powder will probably sit in my fridge for a few more days until I screw the courage to crack it open. ChatGPT estimates around 50% oral bioavailability—the calculation is highly speculative though.
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Nice. I’ve been thinking about getting some myself.
Update for everyone on the project: The study has been added to the queue of studies. I don’t know exactly when it will start.
Since IPAM increased the size of rotifers in the 2010 study I asked Ora to look at the size of the treated worms vs the control group. I would like to get photos of them as well if possible. This will be an interesting data point.
Any updates on ordering IPAM? Did you guys try it yet? @joseph @medaura @tananth
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Still in the fridge. Still unopened. I’ve had some family commitments on my plate so waiting for a quiet day to start.
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Took 2mg IPAM per day for last 3 days: the liquid version came in a glycol (glycerine?) base, which is used in cough syrups and is supposed to be mildly sweet, but just the 0.33 cc of this syrup was bitter in taste : presumably IPAM is bitter.
No noticeble effect so far, but I had mild bowel upset last night, so skipping IPAM today, just in case. Most likely my heavy dose of probiotics (close to 1 trillion CFUs, my normal dose every other day) is the cause, though it normally does not cause it.
Update: Turns out glycol (specifically PEG-400) tastes mildly sweet to some people, but bitter sweet to others. So maybe IPAM is not responsible for the my bitter taste.
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What company did you get IPAM from?
Thanks for the update, interested to hear more as you continue.
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I used the liquid IPAM from Umbrella Labs 6mg/ml, using 0.33 ml per day (approx). As mentioned above I paid $100 for 4 bottles of 30ml (180mg IPAM) each on the Memorial day sale.
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FYI it’s estimated that roughly half the oral dose taken gets systemically absorbed so maybe 1 mg / day effective dose doesn’t do much.
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True, but presumably the mice (whose 0.3mg/kg dosage translated to 1.8 mg/day for a 70kg human) have the same 50% bioavailability ?
Another study used 0.5mg/kg for the mice, which would translate to 3 mg/day for a 70kg human : That would be 0.5 ml/day of the Umbrella Labs solution, which might be easier to measure than 0.33 ml/day.
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Medaura, do you have anything you can mention about how you’ve used ibutamoren and what it’s effects have been. Thanks.
I’m not using it myself. One of my children is 3-4th percentile in height and no appetite so I just started at the dose given in the phase 2 clinical trial vs hgh injections. It’s supposed to take 1-2 weeks for appetite to pick up and for her it already is in less than a week. Not a ravenous appetite but considerably better than baseline. She’s already gained almost a pound in a week which is major for her, though it could be partly water retention. Still, it seems to be working. You can read about the trial and how it performs vs hgh.
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Quick report on my first IPAM experience.
Source: Umbrella Labs, 1g powder. It’s a white powder that is someone sticky, which makes it challenging to work with.
Dose: Attempted to allocate 2mg to capsules, but my scale is not precise enough to measure that accurately. Dosage likely in the 2-5mg range.
Objective: I have a stutter and according to this theory, stuttering may partially be due to low neuronal energy supply in certain areas of the brain. Since IPAM should help facilitate ATP production, maybe it can help reduce stuttering?
Results: 
High chance of placebo - speech was very fluent yesterday, and even into today (I did not dose today, see side effects). Blocks and repetitions were minor, and would likely be viewed as normal speech hesitations in a person without a stutter. Vocal cords felt very relaxed and my voice felt a lot less tense, or forced, than usual.
Other positives: was very focused and productive, got a lot of work done yesterday and did not procrastinate on some of tedious things. I also felt hungrier and ate more than usual, list this under positives becomes I am slightly underweight (BMI < 20).
Side effects: insomnia, only got 3-4 hours of sleep last night. Teeth grinding at night too, which rarely happens to me, the grinding broke up my sleep and happened often last night. Because of insomnia, I did not dose again today. And despite the sleep deprivation, I feel functional and my speech is still good today (this may just be skewed perception from lack of sleep).
I will test this again and likely dissolve in a liquid (what liquid? ChatGPT is telling me it may not be very water soluble) to get more precise dosing. Will start lower and work my way up to find the right balance between beneficial and side effects if possible.
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You might find an adjustment in terms of sleep energy and if you take it on a longer timescale the insomnia stops. Like mk7
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