Came to pay and then it’s already done (unless we want to do more?). Thanks to all the contributors! Now wait and see… 
7 Likes
I appreciate your enthusiasm. If you are wanting to fund something that will further our understanding then please donate to the Rapamycin Longevity Labs 601 mTOR inhibitor project! Crowdfunding Project Looks for a “Better Rapamycin”
3 Likes
I’m sooo looking forward to this. Wish we could follow the experiments in real time. That would be awesome 
2 Likes
Gave to that one, will wait for the results. I have also quite a few ongoing ones…
2 Likes
Nice. Keep us updated on the ones you paid for. What ones did you do?
I think I already posted in Ora Biomedical Million Molecule Challenge Results (including those waiting for results). I post whenever I have new results.
2 Likes
“The 10% fee is applied to all orders and helps cover processing, handling, storage of drug, licensing fees, and taxes.”
They should quote a price including the “fee” then.
6 Likes
Agreed. I paid the 10% also… if I hadn’t already committed to chipping in $100, I would’ve reduced or cancelled my donation altogether. They probably lose a few people who’d otherwise be donating when they introduce this 10% fee. It’d be MUCH better just to incorporate it into the price upfront!
4 Likes
When I donated to
Rapamycin Longevity Labs 601 mTOR inhibitor project! Crowdfunding Project Looks for a “Better Rapamycin”
Around the same time - there was no 10% fee there…
1 Like
When I get more information from Ora I will make a post here. I will likely make a new post once the results are in.
3 Likes
My goodies have arrived but now I’m getting a bit gun shy. The jar of powder will probably sit in my fridge for a few more days until I screw the courage to crack it open. ChatGPT estimates around 50% oral bioavailability—the calculation is highly speculative though.
5 Likes
Nice. I’ve been thinking about getting some myself.
Update for everyone on the project: The study has been added to the queue of studies. I don’t know exactly when it will start.
Since IPAM increased the size of rotifers in the 2010 study I asked Ora to look at the size of the treated worms vs the control group. I would like to get photos of them as well if possible. This will be an interesting data point.
Any updates on ordering IPAM? Did you guys try it yet? @joseph @medaura @tananth
4 Likes
Still in the fridge. Still unopened. I’ve had some family commitments on my plate so waiting for a quiet day to start.
1 Like
Took 2mg IPAM per day for last 3 days: the liquid version came in a glycol (glycerine?) base, which is used in cough syrups and is supposed to be mildly sweet, but just the 0.33 cc of this syrup was bitter in taste : presumably IPAM is bitter.
No noticeble effect so far, but I had mild bowel upset last night, so skipping IPAM today, just in case. Most likely my heavy dose of probiotics (close to 1 trillion CFUs, my normal dose every other day) is the cause, though it normally does not cause it.
Update: Turns out glycol (specifically PEG-400) tastes mildly sweet to some people, but bitter sweet to others. So maybe IPAM is not responsible for the my bitter taste.
4 Likes
What company did you get IPAM from?
Thanks for the update, interested to hear more as you continue.
1 Like
I used the liquid IPAM from Umbrella Labs 6mg/ml, using 0.33 ml per day (approx). As mentioned above I paid $100 for 4 bottles of 30ml (180mg IPAM) each on the Memorial day sale.
2 Likes
FYI it’s estimated that roughly half the oral dose taken gets systemically absorbed so maybe 1 mg / day effective dose doesn’t do much.
2 Likes
True, but presumably the mice (whose 0.3mg/kg dosage translated to 1.8 mg/day for a 70kg human) have the same 50% bioavailability ?
Another study used 0.5mg/kg for the mice, which would translate to 3 mg/day for a 70kg human : That would be 0.5 ml/day of the Umbrella Labs solution, which might be easier to measure than 0.33 ml/day.
3 Likes