Just an update that the trial has started. It will be awhile until we see results.
World-first: therapy to make cells young again given to a person
The first participant has been treated in a landmark clinical trial of cellular reprogramming, which aims to rejuvenate ageing cells.
Chairman and Co-Founder of Life Biosciences - David Sinclair.
Within this i think encouraging extra mitophagy is good (SOX2), but the other Yamanaka factors raise questions. This experiment will inform us. There are lots of doubts about the effects of Yamanaka stimulation.
I thought I would get a chatGPT deep research on this. I have downloaded that to PDF and attach it to this message.
Summary:My (chatGPT) overall judgement is this. ITOT is an important and productive hypothesis, but not an
established general theory of mammalian ageing. The evidence is strong enough to justify serious
work, but not strong enough to demote other ageing mechanisms to secondary status.