The active ingredient Alfatradiol is used to balance an estrogen deficiency in the scalp. The presence of estradiol (female sex hormone) acts like a 5 alpha reductase inhibitor. This inhibits the action of excessive male sex hormone and reduces the formation of dihydrotestosterone (DHT). This is important because the immoderate amount of DHT is one of the main causes of hereditary hair loss.
Alfatradiol is a successful topical solution because of its relatively fast onset of action. After a continuous use for approximately twelve weeks, the product has been clinically shown to noticeably increase the hair growth and reduce hair loss. It must be applied for a longer duration to reduce hair loss. Once it is stopped, previously recovered hair will be lost again. Therefore, it should be used continuously for the rest of life.
I don’t “think” we want to be taking the hair tonic formulation that includes 17-alpha estradiol.
As you mentioned, here are the ingredients they list in the german document you linked to. It doesn’t tell you the quantities of each (or proportion) - so its a little hard to know, but probably lots of water.
Was pantostin enthält:
Der Wirkstoff ist:
1 ml pantostin enthält
Alfatradiol 0,25 mg
Die sonstigen Bestandteile sind:
Propan-2-ol, Glycerol 85 %, myo-Inositol, gereinigtes Wasser
Wie pantostin aussieht und Inhalt der Packung:
pantostin ist als Lösung in Flaschen zu 100 ml, 2 x 100 ml und 3 x 100 ml (jeweils mit Kopfhaut-Applikator) erhältlich.
Google translate tells me this is, in english:
What pantostin contains:
The active ingredient is:
1 ml pantostin contains
Alfatradiol 0.25 mg
The other ingredients are:
Propan-2-ol, glycerol 85%, myo-inositol, purified water
What pantostin looks like and contents of the pack
pantostin is available as a solution in bottles of 100 ml, 2 x 100 ml and 3 x 100 ml (each with a scalp applicator).
Here are some assessments on the toxicity of the different compounds:
Is propan 2 ol drinkable?
It has a slightly bitter taste, and is not safe to drink.
Source: Isopropyl alcohol - Wikipedia
Myo-inositol
Are there any dangers associated with taking inositol? Inositol is generally considered safe in adults. Side effects, if any, tend to be mild and may include nausea, stomach pain, tiredness, headache, and dizziness . Most side effects occur with doses greater than 12 grams per day.
Source: Inositol: Benefits, Side Effects, Dosage, Interactions
It appears that the 17-alpha estradiol powder pretty stable and can be stored for a long period of time without problems. Once its mixed with DMSO it seems to have a pretty short life. But its a bit of a hassle to do the mixture; people probably don’t want to be making this every day.
Going forward, Do you plan to make a week or two of this formula, and store it (in a refrigerator or freezer) for use, then make another batch?
I’m just trying to figure out the practical implementation aspects of this.
Please try to make it a clean test so you know if its actually working for you (i.e. don’t change anything else in your supplement / drug stack so you know any changes are likely due to the 17AE. )
The better our data is for our personal experiments like this, the more we can all learn from them!
Please also share your testing plan as you develop it.
It seems that we want to test in two or three general areas; benefits (given the past studies, where would we expect to see measureable beneficial changes in physiology), negative side effects to watch for (e.g. testosterone reduction, increases in beta-estradiol (estradiol) levels), and then also just validation that the 17AE is actually getting into our bodies systemically… and this seems like it might be a little more difficult to measure given the apparent lack of commercial/consumer blood tests for 17AE. Given this lack, can anyone think of any good ways to identify (via some sort of blood test) whether the 17AE is actually getting into our blood system, and at what level? This would be valuable to know as we test different dosing levels.
it cost me 180 euro so that’s 193 dollar. I will definately include beta-estradiol in my before and after blood tests. Testorerone reduction will not be assessable in my case, because I am on TRT. After 3 months if I notice no side effects, I plan to up the dose to 2mg/day , because I really believe in this compound. I will also post my total Regime here next week:
An anyone comment in detail on the relative merits (generally) of delivering hormone supplementation via oral, topical cream or patch, or injection… Is there one way that is clearly better or more cost effective? (from our experience with female estradiol use, or male testosterone supplementation).
For Europeans 300 ml Pantostin costs 47 USD excluding shipping, which at 0.25 mg / ml would be 75 doses of 1 mg. Around 20 USD a month for 1 mg a day or 7 mg once a week, if everything is absorbed and is correct. OTC.
For Americans it’s apparently possible to buy it on Ebay from Germany, but shipping will probably cost a lot.
Anyone have thoughts on using Pantostin topically for 17α-Estradiol?
In terms of testosterone I think injection is probably most effective but annoying to do. Oral I would avoid, I believe it can hurt the liver. Patches sound convenient, I see that’s what Bryan Johnson is using
Gotta agree with Kris.
Weekly injection - in thigh…switch legs each week. My dose is 1 ml 200 mg.
Almost 4 years now… helps maintain toned body… no fat…and muscles maintaied… strength solid.
My body toned appearance looks exact same … no physical change or feel any different in 4 years of use. Hanging in suspension. Which is great at 65 years.
I see a variety of physicians for urology, manual body adjustment, dermatology and those who assist them. All amazed at my extreme good shape and know I am on rapamycin.
I am not a gym hulk… I am a solid, shredded, veined out tone guy. I asked one young doc do I looked toned for my age? His reply, “You looked toned for any age!”
It definitely works well in combination with rapamycin. I like to think any negatves of testosterone are countered by rapamycin. Keeping heart and blood in great shape.
I was reluctant to start TRT… bad press and such… a lot of that previous attitude is changed. Old men need more testosterone to function healthier. You lose T as you get older… it significantly can help in your health and vitality.
My advice for 50 years and up…if you are thinking you might need a boost… you probably do.
I appreciate reading about your experience with 17-Alpha Estradiol, and getting your recommendations for its preparation and dosing. After reading through your posts, I have a few questions:
• Early on you had an acne breakout and cut back from 1mg to 0.5mg daily. What happened to the acne? What made you decide to resume taking 1mg per day?
• When you wrote that you’d been taking 1mg/day of 17aE2 for 100 days, had you been taking orally after dissolution in DMSO and then mixed with MCT oil?
• If so, and if you were getting good results, why did you switch to taking it sublingually?
• Have your results with 1mg/day sublingual 17aE2 been worse, equal, or better than when taking it orally with MCT oil?
It would be interesting to know why Bryan is taking it weekly. Does 17AE have any side effects that warrant dosing it weekly? Or isn’t that why rapa is typically used weekly or biweekly?
Here is the exact spot in the video where he talks about it…
yes, its obviously 17 alpha estradiol, why he’s dosing weekly? I guess it all comes down to the proportion of the 17AE in his formulation, how much he puts on that one day of the week, and any potential side effects he’s experiencing…
I wonder if higher doses of 17AE impacts his testosterone levels?
Can you please share a little more about the 17 alpha estradiol topical cream that Bryan is using and talking about in the video? What dosing (mg/per application) do you target for a weekly dose? Why weekly? Why not daily? Why cream rather than the oral option?
Will you be making this available commercially? (in Europe if not in the USA, as I don’t believe that 17AE is yet approved for even topical use by the FDA, but I may be wrong on this).
An ester could possibly be added to the 17 Alpha Estradiol to make it fat soluble. Also something to look into is if the 17AE will cause a suppression of androgen production if the body senses it the same as 17BA.
