Thanks @RapAdmin for the great work you do on these boards. From the list you posted (42 compounds) I guess there is few other substances to experiment with. So, for now I’ve decided to not pursue the 17 A Estradiol, but I am cautiously starting many others on the list. This is what I’ve decided on and have started using regularly in last few days:
Accarbose-50mg twice a day with lunch and dinner (regardless of type of food)
Rapamycin once daily with spoon of EVOO (Monday 2mg, Tuesday-Friday 1mg, no weekends)
Empa 8mg or Cana 100 mg with dinner
Metformin 500mg before bed
Captopril 25mg-50mg daily
UDCA 300mg daily
Daily Glycine with coffee about 5-10g (replacing sugar)
4.5mg of LDN each evening
6mg Tirze or 4mg Reta weekly (still need to lose about 10-15lbs, will decrease dose when ideal weight reached)
3IU Growth hormone five days a week
250mcg HCG three times weekly
5mg Cialis daily/mornings
100mg DHEA daily
10mg Ezetimibe daily
2mg Pita daily
Light to moderate exercise 3-4 times weekly.
I have plenty of supplements and might do some of them sparingly (as needed) but not focusing heavily on sups for the moment.
So far zero side effects, and I feel noticeably better than before starting this regimen (better than I have felt in last 20 years or so). Intend to do blood tests every six months (did one 3 weeks ago prior to starting most of the items on the list). Still contemplating on doing everything Mon-Friday and stay free of all substances on weekends (to let body adjust/cleanup)
edit. I could not help but notice how cheap all these amazing substances are when sourced from India, everything for less than $5 a day. It would literally be over $100 per day if bought in USA (out of reach for most people). Uneffing real…
Nothing in the list is with prescription. for peptides and Glp1’s I get the supplier info mainly on GLP1 forums. Plenty of choices and I usually buy from ones that have USA warehouses since it is easier to order and faster.
Agree 100% that @RapAdmin is outstanding at moderating/adminsitering this board. Thank-you!
My order of Ell-Cranell with Alfatradiol has shipped. I have some male pattern baldness and will apply to my scalp with transcutol if it arrives. I will monitor hormone levels after a couple months. 17 A E is one of the best longevity options for men from the ITP studies, and is worth a try.
In fact, I am finding there are relatively few very pure creams out there OTC. I asked chatGPT 5.1 for the purest estriol gels that were available:
Short answer: there really isn’t a truly “just estriol in a super-simple gel” product you can buy OTC in the US; that kind of minimalist gel is basically a compounding-pharmacy thing (and needs an Rx).
But going through what’s currently purchasable online, the cleanest, least-fussy estriol cream I can actually find (no Rx, paraben-free, relatively short ingredient list) is:
I haven’t really tried most of these. I mainly looked through the ingredient lists because a lot of the OTC creams have way more additives than people expect, and Platt’s looked like the cleanest of the easily available ones. A better one would be Aspen’s Evalon cream, but that is a prescription product where I am at.
I received the Pantostin with 0.25% Alfatradiol yesterday from 24Chemist in Portugal. It took only 8 days from the time I placed the order. They ship to US only with Fedex International Expedited. No tariff paid. This product contains only the alpha isomer. Since I have some male pattern alopecia I will begin applying to my scalp. I’ve ordered transcutol as well (delivery pending) that will enhance transcutaeuous absorption.
Interesting that you are doing this in conjunction with Enclomiphene. My concern with that is that you might override the inhibition by Enclomiphene at the hypothalamus if estrogen levels became too high from exogenous sources. Do you have any further updates since your posts here in March?
Hey, because of acne side effects I didn’t continu with the experiment. But because I believe that having a higher estrogen is a good thing for longevity, I started using HCG 500IE weekly besides TRT. This keeps my estrogen high, even above what is considered the “normal” range
I personally wouldn’t worry about the dose you are taking, in fertility protocols they use simular doses.
I started TRT at 39 and if I could go back in time I would have tried HCG or clomid therapy first instead of going on TRT. Just because TRT is a life long commitment
What was horrible for you? That it didn’t raise T, or side effects? I have been on 833 IU of HCG for 3 years now and it’s been wonderful. Raised my T, especially free-T, close to top of range, and I feel sooo much more vital. Gained 15 lbs of muscle while losing .25 lbs of fat in the first 5 months without changing anything about my strength training or diet. That’s plateaued substantially around + 20lbs muscle.
