Re Apollo, drilled down into their stable of companies.
Did you see this one:
“Aeovian Pharmaceuticals is a San Francisco Bay Area-based R&D-stage biopharmaceutical company developing novel and highly selective therapeutics modulating the mTORC1 pathway.
Addressing the mTORC1 pathway has been challenging to-date however, because chronic treatment with conventional, non-selective mTOR inhibitors, such as rapamycin and Everolimus, leads to off-target inhibition of mTORC2 which results in dose-limiting deleterious effects on metabolic health and immune function. The associated toxicity leads to severe clinical adverse events that significantly reduce treatment safety, decrease compliance, and compromise therapeutic efficacy.
In contrast, by virtue of their selectivity, our compounds potently inhibit mTORC1, but avoid inhibition of mTORC2, and therefore are not expected to cause the mTORC2-related side effects that limit the conventional non-selective mTOR inhibitors. We believe that the exquisite selectivity of our compounds for mTORC1 will enable a significantly improved safety profile resulting in improved tolerability, patient compliance, and ultimately improved efficacy in treating mTORC1-mediated rare and age-related diseases.
Our proprietary platform is supported by an extensive intellectual property portfolio, part of which has been obtained by assignment from the Buck Institute of Novato, California, the nation’s first independent research facility focused solely on understanding the connection between aging and chronic disease.”
Lamming is a scientific advisor.