Your experiences using Supplemental BHB esters to reduce blood glucose, appetite, triglycerides, free fatty acids, Slow Aging, etc?

[jjrap1]

@desertshores, can you share the brand you are using; checking Amazon, there seem to be quite a variation in costs and claims for efficacy.

[desertshores]

I use the powder form, not that I think it is better. I whisk it in with a little blender.
Nutricost
C8 MCT Oil Powder 1LB (16.2oz) - 95% C8 MCT Oil Powder

[Viracocha]

I thought on posting this in a different topic just to warn everyone, the formulation is super important if you want ketones to be healthy:

“Divergent Hepatic Outcomes of Chronic Ketone Supplementation: Ketone Salts Preserve Liver Health While Ketone Esters and Precursors Drive Inflammation and Steatosis“

https://www.mdpi.com/1424-8247/18/10/1436

This gives us light why the study shared in a post before this one showed increased mortality following ketone supplementation:

Ketone bodies: A double-edged sword for mammalian life span - PubMed

First of all, Salts seem to be the only formulation that is safe. Second, the speed at which you saturate the body seems to also be important. I imagine is the same as Fructose and alcohol, if the step needs ATP, the slower you ingest it, the less crisis you generate.

[John_Hemming]

Conflicts of Interest

International Patent # PCT/US2014/031237, University of South Florida, D.P. D’Agostino, S. Kesl, Patrick Arnold, “Compositions and Methods for Producing Elevated and Sustained Ketosis”. Patent: US 10,980,764 B1, C. Ari, D.P. D’Agostino, “Exogenous ketone supplements for reducing anxiety-related behavior”; Ari, C., D’Agostino, D.P. Technology Title: “Exogenous Ketone Supplementation Improved Motor Function in Sprague-Dawley Rats”. USF Ref. No: 16A019; Ari, C., D’Agostino, D.P. Technology Title: “Lowering of Blood Glucose in Exercising and Non-Exercising Rats Following Administration of Exogenous Ketones and Ketone Formulas”. USF Ref. No: 16A049; Ari, C., D’Agostino, D.P. Technology Title: “Neuroregeneration improved by ketone”. USF Ref. No: 16B128 (provisional patent); Patent: US 10,945,975 B2: Ari, C., D’Agostino, D.P., Dean, J.B. Technology Title: “Delaying latency to seizure by combinations of ketone supplements”. Non provisional patent No. 210112–9018-US02 for AC and DPD. Technology Title: “Methods of Increasing Latency of Anesthetic Induction Using Ketone Supplementation”. US Patent Application No. 17/576,375, patent: Z. Kovacs, C. Ari, D.P. D’Agostino: “Ketone supplements evoked effect on absence epilepsy by coadministration of Uridine”. D.P. D’Agostino and C. Ari are the co-owners of the company Ketone Technologies LLC, and C. Ari is the owner of Fortis World LLC. These interests have been reviewed and managed by the University in accordance with its Institutional and Individual Conflict of Interest policies. All authors declare that there are no additional conflicts of interest.

[cl-user]

Adding to this that his wife founded ketone salt companies:

Dr. Csilla Ari D’Agostino, wife of researcher Dominic D’Agostino, is the co-founder and CEO of Ketone Technologies, a company focused on ketone research, and Audacious Nutrition , which offers products like KetoStart, indicating her involvement in developing and bringing ketone supplements to market. She co-founded Ketone Technologies, a company focused on metabolic therapies, and her work supports the development of products like those from Audacious Nutrition, which feature KetoStart.

Audacious Nutrition - ABOUT THE FOUNDER

[Viracocha]

Another source supports that MCT causes steatosis in the liver. This time from a different lab and a different animal, mice:
https://www.sciencedirect.com/science/article/abs/pii/S0952327818301947

[desertshores]

[quote=“Viracocha, post:26, topic:4973”]

steatosis

Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice

[Viracocha]

That’s the title of the study, yes. If your point is that it only happened with fructose you should read the study. If your point is another one, please clarify.

[desertshores]

@Viracocha

please clarify.

I should have been more clear.

A. It is a mouse study: The correlation as it relates to humans is not that high, 20 - 40%

They used C57bl/6 mice, mice that are prone to have these results. This means that I have little respect for the study.

C57bl/6 mice:

Metabolism & body composition

• Prone to diet-induced obesity
• Rapid weight gain on high-fat diets

Develop:

• Insulin resistance
• Hyperglycemia
• Fatty liver (NAFLD)

Implication:

They over-respond to Western diets → metabolic interventions often look stronger than they are in humans.

1. MCT (C-MCT) = detrimental hepatic effects and should be used with caution,
2. Fructose (F) = increased water intake and blood pressure associated with hepatic steatosis.
3. fructose with MCT (F-MCT) = showed hepatic steatosis and inflammation in the liver,

"Highlights

•Fructose increased liver lipogenesis and inflammation, and reduced beta-oxidation.

•MCT and fructose led to marked fat accumulation (steatosis) within the hepatocytes.

•MCT intake did not revert or attenuate the hepatic damage caused by fructose.

So, even with these mice, the effect of MCTs wasn’t that great.
Ref1

Ref2