By now we have all heard about epigenetic reprogramming and its successes. More than one lab has achieved epigenetic age reversal in mice. The epigenetic age of mice can be manipulated using various combinations of Yamanaka factors, reversing and accelerating the age at will. Very notably, the Sinclair lab demonstrated that reversing epigenetic age in the optic nerves of mice enabled them to regrow and restore vision in mice that had been completely blinded.
Yet we still have not seen an actual mouse that has lived more than 10-20% longer than average using these techniques. Why not?
In theory, if you can reverse the epigenetic age, and epigenetic age seems to control the phenotypic age of cells, why are we not seeing mice that live 2,3,5,100x longer than average? What is the disconnect?
We have seen it with injected or fed DNA/RNA mix. Less with RNA alone. Maybe someone should ask well-known aging researchers if they know about the six rodent studies and why no one is trying to discover the mechanism. A 50:50 DNA:RNA mix should be a top priority for ITP to see if these old studies can be validated.
Only half joking:
Some well respected scientists believe we may be living in a computer simulation, Sim City, as it were.
Lisa Randall at Harvard
Sabine Hossenfelder of the Frankfurt Institute for Advanced Studies
David Deutsch at Oxford
Zohar Ringel
Dmitry Kovrizhin
and many others, along with Elon Musk.
Dr Melvin Vopson published the research in AIP Advances which suggests that the universe behaves just like a computer, ordering and deleting unnecessary information
As we approach the speed of light it becomes harder and harder to go any faster. The speed of light of course is probably the maxispeed the computer can process the simulation.
As we approach the absolute maximum limit of the life the computer simulation allows, the harder it will be to get any older. Fewer and fewer people are near the limit. Maybe no one has achieved the absolute limit yet, but if we live in a simulation, there is surely a limit.
The Sinclair group has only been able to rejuvenate discrete organs/tissues (optic nerves), not the whole body. Perhaps, it is because different organs age differently.
It’s much more difficult than one might think to epigenetically rejuvenate cells. In vitro, when applying reprogramming coctails, you often see just a tiny fraction of the cells being reprogrammed. Delivery is a major problem and also controlling the exact reprogramming. What Sinclair did was far from whole body epigenetic rejuvenation. His research is overhyped in the media.
Even if you could epigenetically rejuvenate all the cells of a mouse, I don’t think it would result in the mouse living twice as long. Epigenetic rejuvenation only fixes some aspects of aging. There are plenty of things it doesn’t fix.
