Why do you take or not take Rapamycin?

#21

Hey macneu,
My Rapamycin is physician prescribed.

He and I agreed that I would do blood work ever 3-4 months while on rapamycin. That included getting Labcorp rapamycin/siriolimus blood draw at trough; then, dose my rapamycin… currently 2mg pill and fresh squeezed Pink Grapefruit (about 5 oz).

Next, 2.5 hours after that dose take a second Labcorp blood draw to get c-max. All insurance covered.That dose with GFJ, gives me about 8.8 ng/mL.

I probably know how much my rapamycin dose is distributed through my cells… than most on this site.

When, I was high 38 ng/mL my biological age faster. On 6mg I get a reversal of age and no inflammation.

I recommend no more than 6-10 mg once weekly.

Hope that helps.

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#22

So it’s scientific rather than your “phenotype and blood group 0”.
Thank you!

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#23

So, is that 6-10mg “naked,” meaning no GFJ? You often take 2mg w/ GFJ = ~14mg equivalent, or you used to…

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#24

Hey Justin - I have been taking 4mg Zydus ( rapamycin) with a Red Grapefruit juice chaser - about 5 fluid ounces. So about a12 mg dose. I have been getting a 24 ng/mL measure on a labcorp test at 2 hours post dosing. Close to what Matt Kaeberlein gets on straight 8 mg no GFJ. So I am happy sticking with it.

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#25

You’ll note that long-time users will vary their dosages to try things out. For instance, I usually try 10-14 mg eq. (3-4 mg + GFJ) weekly or every 2 weeks. @Agetron seems to be doing the same.

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