Which GLP-1RA is best for anti-aging?

#1

There are already over a dozen GLP-1RAs out there, and new ones keep popping up. A lot of reviews tend to lump them all together when talking about anti-aging, but I’m curious—which specific GLP-1RA do you think is best for anti-aging, and why?

Would love to hear your latest thoughts and personal insights. What’s your take?

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#2

It depends. Retatrutide seems to be great for liver health and cholesterol but can also cause your resting heart rate to go into overdrive. Tirzepatide seems better for inflammation management.

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#3

I don’t think we know the answer to this question.

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#4

Depends on what you are determining as “anti-aging” which is not a very well defined term.
What are you trying to accomplish? What are you treating?

#5

Going strictly by available data/signals so far, you can’t go wrong with semaglutide. See these posts below.

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#6

Thank you so much for your answer! I totally agree with you. I actually have one more question for you: How do you feel about people with a low BMI using semaglutide purely for its cardiovascular benefits?

#7

It’s a gamble I’m comfortable taking. Analysis of semaglutide SELECT trial shows that the reduction of mace from it has only a small association with baseline weight and weight loss.

Weight independent protection could come from :

  • Direct Vascular Activation: GLP-1 receptors on vascular endothelial cells increase nitric oxide production, improving endothelial dysfunction independently of metabolic changes.
  • reduction of hsCRP
  • ​Plaque Stabilization, only demonstrated in pré clinical and translational studies
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