At 80, high levels of NAC need a kidney function check.
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Review the original paper, it is 1.33mg per kg of body weight.for the glycine
On other threads on this forum is a link to the original paper
AI is not correct all the time
AI-generated answer.
Please verify critical facts.
…a simplified rule of 100 mg/kg/day for both compounds, which aligns with the molar calculations used in the trials (approx. 6.7 g glycine and 6.7 g NAC for a 70 kg person).
AI-generated answer.
Please verify critical facts.
A memory stack that works for me: (By that I mean that I definitely feel subjective results.)
Galantamine, 8 mg, morning and evening (don’t take right before bedtime unless you want vivid dreams).
Bacopa Monnieri, 2 grams, standardized to 50% Bacosides
L-Ergothioneine (EGT) 25 mg morning and evening.
Cognizin Citicoline, 500 mg, morning and evening. There is no head-to-head clinical evidence proving that Cognizin is biologically superior to plain, generic citicoline (CDP-choline) of equal purity.
C8 oil powder, 8 grams, in my morning coffee
Creatine, 8-10 grams, in my morning coffee. There is a growing body of clinical evidence that creatine aids cognition—specifically memory and executive function, mostly in older adults.
I do take NAC, glycine, etc., but not specifically for memory.
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Good to know, thanks!
Yeah, that’s a much higher dosage. Thanks for the clarification.
That’s a nice stack for sure. I’ll tell him about this, and that you are in your 80’s as well IIRC.
Looks like you dropped the modafinil.
Aside from ruining a great pour over 
, do you find that you get a consistent energy boost from C8 oil powder? Is AM the only time you take it?
Some things to consider: read about them as they are not studied via any vigorous RCT’s.
Lithium orotate: I take 1 mg daily. Was taking 5 mg. Developed edema and read that lithium orotate can cause. No edema at 1 mg
Intranasal insulin --have been taking for over a year. Cannot tell if it has helped but no bad effects.
PDE5 inhibitor, eg tadalafil --purportedly enhances blood/oxygen perfusion in the brain. Have been taking for about a year, and no effects that I can perceive.
So, these are three low risk, inexpensive interventions with some suggestive data but nothing conclusive.
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Once they got good at typing using the game perhaps they should have started writing more often? Writing is quite mentally stimulating.
Yes stop after 3pm at least. Decaf can be used after this time.
I wouldn’t jump straight to this. Try high dose glycine and taurine. Up to 30g glycine and 6g taurine. Try to alter caffeine intake. Utilize exercise during the day to make them more sleepy at night. Morning sunlight exposure, and reduce blue light exposure later in the night. Try everything that isn’t a sleep drug first.
Yes look into this. This sometimes is all it can take to give people zest for life back.
I’m not seeing the word “exercise” anywhere in this. I’d also start a cautious exercise regimen to build muscle, strength, cardio and flexibility. Start small, slowly build up.
Creatine is good for this age group. I’d probably go higher protein. Modafinil is fun but I would resolve the caffeine, exercise, hormone and sleep issues first before adding in additional levers like this.
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I agree with this choice.
No insulin at this time because they do run low blood sugars already sometimes with their stack + nutrition, so they gotta be careful.
Lithium would be a hard sell, but I think it would be good to try.
Yeah, keeping up with the writing would have been ideal.
They prefer watching tv & movies, and reading books.
I agree but he does not like decaf.
Haha he’s not like us here with high dose amino acids and other supplements.
Would be a good idea to perhaps try baking something like a big cookie or donut with the creatine, glycine, taurine and whatever else. That’s the only way I could see someone like him taking many supplements at once.
Walking or house work is the only exercise.
I’ve asked him to workout at the gym, or try push ups - the reply was a no to both.
Saw some good stuff on this forum about zopliclone from a study, so that’s why I mentioned it.
Actually, this thread was made back in Nov 2025, so I just updated it this week with the blood testosterone result above which was 483. Much higher than I expected.
Creatine would be a solid choice.
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No, I have not dropped modafiinil.
I take it primary to lift old age morning fog and for it’s wakefulness properties.
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Exercise ergometer aim to reach 100 watt / 45 min, 3 times a week.
Multivitamin, Centrum Silver if it’s not too large, to reduce morbidity from nutrient deficiencies and improve cognition.
Encourage healthy eating and hydration but recognize appetite might reduce so eating enough becomes important.
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I don’t find that to be true at all. I am particular about my coffee; I grind my coffee beans at the time I make my morning coffee. After the coffee is brewed I add the Nutricost C8 MCT Oil Powder and use a “SIMPLETASTE Milk Frother Handheld Electric Foam Maker, Drink Mixer.” The C8 powder dissolves very well. The C8 powder is very much like adding cream to your coffee. It doesn’t ruin the taste at all.
Basically, I do keto in the morning. No carbohydrates. I eat two meals a day, breakfast and supper, which is not keto. If I feel hungry during the day, I have a protein shake. The object is to keep an even energy level throughout the day.
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Thanks. I was wondering specifically about the C8 but perhaps you have not assessed its near term effects in isolation. I doubt that I could answer that question about many of the supplements I take in combination.
As for the spoons that measure out our lives, I’m pretty sure the world can be neatly divided into two parts: those who tolerate adulteration of their coffee and those who do not.
I am trying to understand why some people suffer from morning grogginess when taking melatonin at night. I take a massive dose, 1 gram at night, and I have no morning grogginess.
I asked Gemini Pro 3.1 for an explanation.
FWIW: (a tidy, selected summary of the relevant answers):
The grogginess isn’t caused by the melatonin itself, but by the fact that the hormone is still active in the bloodstream when the person is trying to wake up.
The morning grogginess people complain about usually comes down to two distinct factors: individual liver metabolism (which explains why your high dose doesn’t bother you) and the exact sleep maintenance issue you pointed out.
Here is what is actually happening beneath the surface.
The “Melatonin Hangover” (Metabolism)
Melatonin is meant to have a very short half-life in the body — typically 20 to 50 minutes. Your liver processes it using an enzyme called CYP1A2.
However, individual livers process this hormone at drastically different speeds:
Fast Metabolizers: Your liver clears melatonin efficiently. Even though you take a very large dose, your body processes it and clears it from your bloodstream before morning. By the time you wake up, your levels have dropped back to their natural daytime baseline.
Slow Metabolizers: Some people have less active CYP1A2 enzymes due to genetics, age, or interactions with other medications. For them, a standard dose lingers in the blood for 8 to 10 hours. When their alarm goes off, their brain is still flooded with a biological “sleep signal,” resulting in that heavy, groggy feeling.
Melatonin is a chronobiotic (a sleep initiator), not a traditional sedative. It signals the brain that it’s time to sleep, reducing the time it takes to nod off. It does almost nothing to maintain sleep. If someone suffers from sleep fragmentation—waking up at 3:00 AM due to a warm room, a blood sugar drop, stress, or sleep apnea—melatonin will not keep them asleep
When these people wake up exhausted the next morning, they often blame melatonin for making them “groggy,” when in reality they are just experiencing the severe fatigue of fragmented, low-quality sleep.
Yeah, it appears many people can handle melatonin in large dosages without issue.
I was searching about this also.
My best guess is that it could be lowering a chemical for day time energy, and it appears to be dopamine at this time.
Melatonin–Dopamine Interactions: From Basic Neurochemistry to a Clinical Setting
Thank you. I did not know that CYP1A2 metabolize melatonin. It might explain why I have a hard time finding a good way to use melatonin. I am a slow metabolizer.
CYP1A2 is also the main enzyme that metabolize caffeine. Which means that some slow metabolizers can have up to 15 times more caffein, than fast metabolizers, from their morning coffee, in their bodies when it is bedtime. An Ai calculation.
If I get a similar effect from melatonin? Then It is no wonder that I have struggled with how to dose melatonin.
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What dosage taladafil do you take and when?
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Not a drug or supplement, sadly, but endorsed by Roy Hood.
If you have not done so, I recommend Attia’s recent podcase on AD and cognitive impairment. It is replete with information of potential relevance to your case. It also disrupts a few common misperceptions about the status of current pharmacological interventions.
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I have not seen it, thanks.
It appears this might be the podcast you are referring to:
This is the one; however, most YouTube versions are introductory teasers but occasionally the member only podcasts are opened up. It looks like this one might be. I listened to audio only when I was traveling so missed some details.