We cannot eat ourselves out of obesity.
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I’m curious about this too it doesn’t seem there’s been any definitive studies about this.I’m 71 and have generally been 20 pounds over ideal weight. I do think some is genetic when I look at the big butts of generations past in my mom’s family, and I’m shaped so much like she was, but I have spells where I just don’t have much appetite and I always lose 6 to 10 pounds then and I’ve wondered if slender people have less appetite all the time. And of course, when I do have more of an appetite, obviously I don’t have the discipline to just be hungry. As for those who are grossly overweight, there must be something wrong with how they metabolize food as don’t see how a person can eat so much to get 100 plus pounds over weight and yet I think I’ve heard that metabolism doesn’t have all that much to do with it. When I was 16, I went on a very strict diet and got down to average 115 pounds. At 5’4.5” this was the weight of most my classmates at that height, and yet I stopped having my period so some bodies must need more weight to function properly? The doctor gave me some thyroid to get it going again.
It’s all very complicated. There are genetic factors, there are metabolic factors, there are gut microbiome factors.
Anyone can just eat less and move more, do that hard enough and you will get results. But different people need different levels of this to get results.
Drugs like tirzepatide, retatrutide and semaglutide completely change the game by causing people to just not crave food as much, have more self-control/willpower, improve insulin response, etc.
I’m doing research on an endogenous gut metabolite (indolepropionamide) right now and I’m finding a lot of evidence that when the upstream processes that lead to it being created are disrupted that people have lower inhibitory control leading to higher chances of obesity and other compulsive behaviors.
“The associations between the SCWT and alterations in tryptophan metabolism were replicated in the Imageomics cohort (n=970), where plasma levels of tryptophan and some microbial-derived tryptophan catabolites (indolepropionamide) were positively associated with the SCWT performance”
Crazy part is when they transplanted the gut microbes from someone who was obese to a mouse the mouse had similar inhibitor control problems: “FMT (Faecal microbiota transplantation) from individuals with obesity led to alterations in mice reversal learning.”
I’m 100% confident that we have all the tools necessary to completely cure obesity, and our repertoire of tools is only going to improve as time goes on.
Oh yes I forgot about the fecal transplants - read a story of one lady gaining a lot of weight when given one from an overweight person. I wonder if it applies to energy too - I have chronic fatigue and have wondered about getting one from my nephew who has such superb energy. That’s another issue I wish more was known about - look at Trump - eats fast food, overweight, doesn’t exercise, sleeps 4-5 hours a night and goes all day and seems to feel great. Don’t mean to start anything political but he’s a prime example and it’s no fair! 
Might work.
Rich, unlimited access to cutting edge drugs, treatments and specialists. No one really knows but I’ve heard speculation that high level officials get legal access to powerful nootropic drugs that allow them to work more effectively but it seems to age them badly.
Here’s a brand new one that’s already passed a phase 1 trial and headed to phase 2. It acts like a mitochondrial uncoupler, but uses the creatine cycle to dissipate energy as heat instead of UCP1. Apparently it’s also selective for fat tissue, so it doesn’t cause the potentially massive increase in body temp seen with toxoc uncoupling drugs like DNP:
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Yikes, I’ll wait to see phase 3 on that one, mitochondrial uncouplers can be very dangerous. I would be curious as to what happens when you overdose on it. Overdosing GLP1s is terrible, but they shouldn’t kill you.
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It seems a lot safer than DNP.
“Chronic administration of SANA (400 mg per kg per day) to normal mice for 8 weeks showed no signs of renal or liver toxicity” (note this is very much unlike the uncoupler DNP, which kills mice at higher doses.
They aren’t going to overdose human subjects in the phase 2 or 3 trials and it’s an oral capsule, so dramatic overdosing would need to be intentional rather than accidental.
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Still wise to avoid until more data comes out. GLP1 agonists are already promising enough as it is imo!
Still cool to see new stuff come out.