Yes, that appears to be the Timeline product. Maybe Timeline is exploring additional outlets for their product, but at a more reasonable price. Or, maybe it’s a limited time low price.
The product appears in your link, but not when accessing the Aeternum site directly. Searching for Urolithin A from the Aeternum.site presents a Urolithin A MitoPure alternative link that requests an email address. I assumed a link to what you found would be given after providing my email address. But, the link Aeternum sent to my email was for a discount code only.
Thx Jay,
I see it’s available directly from Ggvbeauty, however they seem like a questionable website, so maybe this is damaged or expired product. I’d stock up if trustworthy, but ???
And it’s interesting because the link takes me to the page on the Aeternum site. I have noticed in the past there are things available on their Australian site that were not available in the US… including a discount code. Maybe this is one of those inconsistent things.
A very long thread, close to 500 comments and upon review you found one example of benefits claimed? What to make of it? Perhaps indomitable human spirit and hope never dies …
I was going to give up on on UA, but after Claude found this, I was going to continue with a less expensive source… but alas, most have seemed to vanish …
Summary written by Claude (Anthropic’s AI) at my request:
Something newer than most of this thread: a heart finding from an academic lab.
Su et al., Science Advances, August 2026. King’s College London, funded by the British Heart Foundation, not by the Mitopure maker.
What they did
Screened plant compounds for ones that switch on PKGIα, a protein that relaxes heart muscle and blood vessels.
Urolithin A switched it on by directly modifying one spot on the protein (cysteine 42). That is a new mechanism, separate from the mitophagy story.
What they found
Mice with HFpEF (heart failure where the heart pumps normally but is stiff and relaxes poorly): one week of oral urolithin A improved relaxation measures, reduced fibrosis and heart enlargement, and the mice ran more.
Mice engineered without that cysteine got no benefit, so the effect runs through that one switch.
Heart tissue grown from human stem cells contracted and relaxed faster.
What it does not show
No humans. Male mice only. One week of treatment. Human tissue from a single donor.
The mice already had heart failure. It says nothing about prevention in healthy people.
It does not answer the fair criticism upthread. The human muscle trials are small and short, and a July 2026 meta-analysis (Dao et al., Frontiers in Nutrition) rated that evidence low certainty.
Bottom line: a credible new mechanism from a charity-funded academic lab. Evidence tier: animal and lab. Worth watching for a human trial; not proof of benefit.
I mean, I can find no relevance for my health from this finding. A single isolated finding in an engineered mouse model might be grounds for further research avenues, but it says absolutely nothing about taking a dodgy supplement in the hopes of… what exactly I can’t even tell. The whole Urolithin A thing is an incredible boondoggle in being marketed as something somehow useful in humans if but and maybe this and that. I can’t even wrap my head around it. Seriously, this is a plant metabolite originally mediated by the gut biome - yet, there is a mountain more evidence of possible benefits from supplemental carotenoids, sparse as those are.
Until there are minimal human results of any kind at all, run by independent researchers and with a control group, I think this is for the birds. Who (medical profile) exactly is supposed to benefit from this? I’m not opposed to gambling - after all I take rapamycin. But there are - super limited - some kind of rapamycin trials in humans, even if indirect as in transplant patients - that gives me enough information about possible downsides, side effects and drug interactions, so even if there are no benefits that pan out, I at least have an idea about the downside exposure of taking rapamycin. When looking at any drug/supplement you should get both the “cost” and “benefit” parts, even if one (or both!) happen to be null values. What do I get with Urolithin A? I personally can’t see anything at all other than a bunch of pie in the sky promises and prolific mechanistic speculation. But I’m sure others have different views, as always. YMMV.
I am grateful for your thorough analysis, as always. It definitely helps me look at it with more objectivity. Anytime I hear anything with a heart benefit, I say I’M IN!
In the meantime, I got the gummies on a big sale and enjoy them as a treat, but I won’t repurchase them unless we learn more. I appreciate you being my eyes and ears as I can’t personally evaluate things as keenly as you do.
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