Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
RESULTS
Long-term UA treatment significantly improved learning, memory, and olfactory function in different AD transgenic mice. UA also reduced amyloid beta (Aβ) and tau pathologies and enhanced long-term potentiation. UA induced mitophagy via increasing lysosomal functions. UA improved cellular lysosomal function and normalized lysosomal cathepsins, primarily cathepsin Z, to restore lysosomal function in AD, indicating the critical role of cathepsins in UA-induced therapeutic effects on AD.
CONCLUSIONS
Our study highlights the importance of lysosomal dysfunction in AD etiology and points to the high translational potential of UA.
Highlights
Long-term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer’s disease (AD) mice.
UA restored lysosomal functions in part by regulating cathepsin Z (Ctsz) protein.
UA modulates immune responses and AD-specific pathophysiological pathways.
When you do create your own supplement, I look forward to seeing the test results
Here are some results from a little evaluation I conducted with 4 people using the first formula I developed. I supplied the product, they paid for their own testing with a company I trust. www.trudiagnostic.com If anyone is interested in doing this, let me know, I do have a discount code for the test for our participants.
I started UA 3 months ago but I confounded the process with 4 other compounds that show promise. I will be doing our 9 month Trudiagnostic test in September to see if there have been any changes. Yes I will post them, good or bad
Good video today on Modern Healthspan with bits of three different interviews addressing mitochondria. Right near the end, at 26:40, the guest answers the question of which interventions will encourage mitophagy:
Went on Amazon, picked four of the cheap urolithin a brands at random and two of them said they were third party tested.
Very interesting video. Thanks for posting. Regarding Urolithin A, I understand there is only 1 raw material supplier to the brands selling these supplements in the USA, and maybe elsewhere. Make sure you are getting the real stuff.
I don’t know enough about the topic to engage in an argument, but what is Mitopure but Urolithin A, possibly with other minor ingredients? It was revealed to all of us years ago that the secret sauce on the All American Burger was only Thousand Island dressing.
Is a claim of third party testing for the specific ingredient Urolithin A meaningful?
I got a massive discount from doublewood on 3 bottles of their urolithin A so I’ve been using it. It could be junk for all I know but it was too cheap not to take a flyer on it
Double Wood is one of my trusted brands until proven otherwise.
Many of their supplements have been 3rd party tested by various consumer groups.
The lowest score I have ever seen in a 3rd party test was that Double Wood only contained 95% of the claimed strength. That is good enough for me.
If anyone can find legitimate negative tests of their products, I would certainly like to know.
Double Wood makes a Urolithin A supplement but it seems to be out of stock at both Amazon and Double Wood’s sites.
“Currently unavailable.
We don’t know when or if this item will be back in stock.”
They usually do well on consumerlab but not always. Saffron was actually their biggest failure on there.
The thing I wonder is whether Mitopure sells a special type of Urolithin A that no one else sells which is why is so criminally expensive. So could Doublewood be selling an inferior type? That’s what I don’t know.
Yeah, on the basis of its reputation, I bought a bottle of Double Wood Urolithin A too.
A couple of months or so ago, someone here posted that he’d gone through all the Urolithin A brands on Amazon and none of them, except those using Mitopure, were third party tested. Things may have changed. My survey of four cheap brands found two that were. I’m exhausted from the four mouse clicks, but maybe someone hardier can take up the quest. How many more are there?
It’s possible that Mitopure is better. Or it may have had some kind of monopoly on supplies at that point, but no longer does. There have to be many companies capable of manufacturing Urolithin A. Maybe one or more of them saw the demand or potential demand, started making it and supplying brands that can now sell it cheaply.
It will be interesting to see how UA compares to Rapamycin. It is direction of action is the same so should in some way be synergistic. I have, however, not taken both at the same time yet. I have a Rapamycin cycle coming up in a week (I am on 21 days) so I may wait until then to take UA. It has appeared to disrupt sleep in a manner which implies autophagy.
I am doing particularly well with sleep (which was my big issue a few years ago) so I am inclined to concentrate on things that don’t disrupt it whilst I don’t have to get up early (no school for my son at the moment).
That thorough Gemfibrozil studyis pretty damning: some reduction in cardiovascular events, but no change in coronary mortality or all- cause mortality, and a small, non-significant increase in cancer mortality for the Gemfibrozil users.
I wonder how a well-renowned researcher like Brian Kennedy can be so enthusiastic based on great animal data, when long-term human data on Gemfribrozil is so disappointing. He believes that the anti-aging effect in animals is caused by blocking of amino-acid uptake,which in turn blocks MTor. What does this help if no effedt in humans?
Could you expand on that? The two are indeed vastly different, but won’t the disappointing long-term health impact of Gemfibrozil on humans have something to say on the likelihood of an anti-aging effect on humans when the underlying data in that research is based on animals?
