At last!. This is to truly underline the fact this study is the first to my eyes with no competing interests for being funded total or partially by company Amazentis, Mitopure’s brand (urolithin A compound) owner.
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Berberine might be a cheap natural alternative.
“Results: Berberine dramatically alleviated hypertrophy of H9C2 cell line and significantly ameliorated mitochondrial function by rectifying the imbalance of fusion and fission in mitochondrial dynamics. Furthermore, berberine further promoted mitogenesis and cleared the damaged mitochondria via mitophagy. In addition, berberine also restored autophagic flux in high glucose-induced cardiomyocyte injury via AMPK signaling pathway activation.”
The study, however, was in vitro.
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$1,020 per year for Mitopure. $85 per month.
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Funny that Amazentis is a swiss based company that only sells MitoPure in NorthAmerica. 
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I think that as part of the partnership between Nestle and Amazentis, Amazentis perhaps focuses on the NA market, and Nestle the rest of the world?
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Nestlé Health Science is the only investor.
Previously, I purchased rapamycin powder from them. It might be worth considering trying their Urolithin A.
Good news!
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HHDpharm
I really would not trust any chinese middleman company (or smaller producer), as you have no idea on the purity, or the possible contaminants, and no recourse…
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Sweet, my Viome report says I have that guy!
Guess I should start taking Pomegranate extract!
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Drink cold press pomegranate juice.
Not sure I want all the extra sugar…
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Not sure how it spikes the blood sugar, but I eat a lot of pomegranates when they are available. Not an issue if you’re taking acarbose or SGLT2 inhibitor.
| Fruits (mg/100g fresh weight) | |
|---|---|
| Blackberries | 150 |
| Black raspberries | 90 |
| Boysenberries | 70 |
| Cloudberries | 315.1 |
| Pomegranate | 269.9[19] |
| Raspberries | 270 |
| Rose hip | 109.6 |
| Strawberries | 77.6 |
| Strawberry jam | 24.5 |
| Yellow raspberries | 1900 |
DoNotAge.com just started selling Urolithin A for less than Mitopure : $726/year for 500mg/day, plus DoNotAge always has various 10% off coupons available, reducing the cost to around $654/year.
I just paid $1020 for 1 Yr with Mitopure in Dec’22 and am stuck with their price till Dec’23 !
Timeline.com claims Urolithin-A is not present in any food item : the precursor is, but only a certain (unknown) gut bacteria is able to convert it to Urolithin-A and some people must be completely lacking in that gut bacteria since they never test positive for Urolithin-A in their blood.
Update : Sorry I missed your other link which identifies that gut bacteria.
Even Streptococcus thermophilus FUA 329 seems to work.
Only a limited number of studies have been conducted on the microbial species capable of transforming ellagic acid into urolithins. Ellagibacter isourolithifaciens DSM104140T (E. isourolithifaciens DSM104140T) and Gordonibacter urolithinfaciens DSM 27213T (G. urolithinfaciens DSM 27213T) were confirmed to convert ellagic acid to isourolithin A and urolithin C. Only a single strain of Bifidobacterium pseudocatenulatum INIA P815 (B. pseudocatenulatum INIA P815) could produce urolithin A.
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FWIW
Grow your own yellow raspberries at the posted amount showing 1,900mg per 100g of fruit.100g is 3.5274 ounces
Yellow raspberries: How to grow these golden gems in a home garden
In my view this supplement{ Urolithin-A] is overhyped, and overpriced.
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I grow them in South East of UK.
Really easy; prolific growth and fruiting from May until first frost, so basically last year I was eating them for six months.
No idea if I have the relevant gut bacteria but they taste great anyway.
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