Uridine, carotine diol, vanillactate, phenylacetylglutamine, N-acetyl-isoputreanine, ribitol and other OMICm age metabolites (takeaways from OMIC_m age)

[AlexKChen]

Understanding How to Interpret Your OMICm Age Report

N-acetyl-isoputreanine decreases cognitive function
ribitol = hyperlipidemia/hyperglycemia

Paraoxonase - Wikipedia (PON1), detoxifies pesticides, may be increased by chokeberries

[John_Hemming]

My issue with the Omic age reports is that they have considerably different values to the actual biomarkers that I measure each week using a number of labs.

Hence whatever indirect system they are using to measure these is not coming up with a very accurate conclusion.

Eg HbA1c Omic is 6.51, but actually it is pretty well always under 5.

AIUI they are looking at methylation patterns on lymphocytes DNA.

[AlexKChen]

My predicted HbA1c methylation patterns are also way above their normal values of 4.8-4.9, though i ascribed this to me having thick glucose spikes

[Acarb]

Is uridine anti-longevity?

It is good for brain function and tissue repair but bad for longevity? is it worth it? https://www.nature.com/articles/s41421-021-00361-3 When we supplemented the culture medium with uridine, we found that uridine treatment was sufficient to reprogram the prematurely and physiologically aged stem cell models (WS/HGPS (Hutchinson-Gilford progeria syndrome)-hMSCs and hPMSCs) into a younger state with a higher regenerative ability (Fig. 3d–f and Supplementary Fig. S4a–f). Specifically, uridine-treated hMSCs achieved a much higher proliferation rate and an enhanced capacity to form cartilage and gained increased genome and epigenome stability (Fig. 3d–g and Supplementary Fig. S4a–f). In accordance, genome-wide RNA-seq analysis showed that upregulated genes were mainly associated with “cell cycle” and “DNA integrity checkpoint” GO terms or pathways (Fig. 3h). Consistent with a previous study reporting that uridine addition rescues pyrimidine biosynthesis deficiency45, we found that the “…