Several compounds in tubers are linked to enhanced DNA repair and longevity, both via direct biochemical action and through antioxidant effects that protect DNA from damage.
Key Tuber-Derived Compounds
Caffeoylquinic acids (chlorogenic acids): Potent antioxidants found in many tubers that stimulate cellular repair of oxidative DNA damage, helping maintain genome integrity.
Phenolics and flavonoids: Broadly present in tubers such as potatoes, sweet potatoes, and yams, these compounds scavenge free radicals and support excision repair mechanisms, decreasing mutation rates and protecting cells against aging.
Beta-carotene and Vitamin C/E: Vitamins abundant in tubers work as antioxidants, reducing oxidative stress and aiding enzymatic DNA base repair, thus contributing to longevity.
Terpenoids and glycosides: Select tubers harbor bioactive terpenoids and glycosides found to extend lifespan in animal models, partially by upregulating genes involved in stress resistance and DNA repair.
Mechanisms Promoting LongevityAntioxidant compounds reduce DNA damage from metabolic processes and environmental stress.
Some tuber-derived molecules actively stimulate cellular DNA repair pathways, including base excision and homologous recombination, crucial for maintaining stable genetic function throughout aging.
These compounds result in a lower incidence of cancer and age-related diseases, as seen in animal models and suggested by naked mole rats’ exceptional lifespan.
An Okinawa diet!!
2 Likes
Nick this is very interesting. Can you share what the sources are for these two posts above?
