Source: https://x.com/BioavailableNd/status/1980978014532833522
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Hi
Yes I’d be interested in your results. My partner is considering options at 70…
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I don’t have access to X. But I think they’re talking about this 2012 study published in an unknown Iraqi medical journal:
https://mjtu.tu.edu.iq/index.php/mjtu/article/view/539
322-329.pdf (1.7 MB)
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Hmmm… more Ginger Ale please. And, a bit of Jameson Scotch with lime. My go to bar drink.
Ever try backloading insulin syringe with T using 5/16/8mm pin for subQ?
Works better for me although it adds a step and more waste.
I have not. I think the injection site reactions came from not having the needle deep enough in the muscle.
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Understood.
FWIW I’ve done both methods.
Ive had much less reaction using insulin pins as opposed to IM.
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I do not recommend Purerawz.co as a supplier. I have placed several orders with them, but my most recent order was shorted. I initiated a documented email trail explaining the issue and complied with all stated customer service requirements to have the missing product shipped. However, despite multiple follow-up emails, it appears that the customer service representative has lost track of the prior correspondence.
They do not seem to have any effective system for tracking or resolving customer complaints to completion. Once payment has been received, there appears to be little concern for post-sale problem resolution.
I also reviewed Reddit and found several discussions reporting similar negative experiences related to order issues.
Well, if you know of a similar company with a good reputation when it comes to customer complaints let me know.
As a general statement, it should be pointed out that when you check your testosterone level, you should ask for the gold standard Testosterone LC/MS and not the standard immunoassay which can easily be falsely elevated if you’re taking HCG, other androgens, and a few other things. Might as well make sure you get the most accurate test because it really does make a difference.
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Here’s a concise summary of the most important points from that long video transcript about how testosterone metabolites work and why they matter:
• Testosterone is a pro-hormone that gets converted into many downstream metabolites beyond just estradiol (E2) and dihydrotestosterone (DHT). Those metabolites often have distinct biological effects that influence mood, body composition, cognition, immune function, vascular function, and more.
• The common notion that “it’s just testosterone, DHT, and E2” is oversimplified. In reality, testosterone’s metabolism continues far beyond those two pathways, creating many compounds that are biologically active or locally important to tissues.
• DHT itself is only one part of the story. For example, 5-beta DHT and its metabolites don’t bind the androgen receptor but instead appear to support vascular health and nitric oxide-mediated vasodilation, separate from androgenic signaling. Blocking enzymes that produce these can have unintended effects.
• Certain metabolites have neuromodulatory roles. Some act as neurosteroids that influence GABAergic signaling, anxiety, cognition, and memory, while others affect immune responses (like fever induction) by interacting with immune pathways.
• Estradiol and its metabolites are similarly complex. Some downstream estrogen metabolites appear more potent than E2 itself at specific functions like inhibiting inflammatory adhesion molecules that contribute to atherosclerosis or acting as neuroprotective agents.
• The effects of enzyme inhibitors (such as aromatase inhibitors for estrogen or 5-alpha reductase inhibitors for DHT) are not limited to changes in E2 or DHT levels. They can alter levels of multiple metabolites with unpredictable downstream effects because these pathways are interconnected and locally regulated.
• Tissue levels of metabolites often do not correlate with serum levels, so measuring serum hormone concentrations alone can give an incomplete picture of metabolic activity in tissues like brain, vascular endothelium, or prostate.
• Some metabolites may explain clinical phenomena like “steroid flu,” altered fat distribution, or adverse symptoms with drugs like finasteride because they influence pathways far downstream of the initial hormone.
• Overall, the steroid hormone network is highly complex and finely tuned, and simplistic approaches to manipulating testosterone or its downstream products can disrupt important physiological functions.
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I feel the same about taking it as a woman about his age.
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In today’s Nature:
Testosterone therapy is trending. Who really needs it, and why?
Some clinicians are pushing to broaden testosterone use, but there is debate about its benefits and risks.
Is testosterone the next miracle drug? That seemed to be the consensus of an expert panelconvened by the US Food and Drug Administration (FDA) in December. It argued for major changes in policy that would expand access to the hormone for people with a range of conditions. Committee members called testosterone replacement “a cornerstone of preventive health” and “a multibillion-dollar preventive-care opportunity”.
Testosterone is already available in the United States for people who have low levels of the hormone owing to a known medical issue, such as testicular damage. But evidence is growing that more men — and women — might benefit from the hormone, which is delivered through injections, patches, subcutaneous implants or gels. (This article uses ‘men’ and ‘women’ to reflect the language used by the panels and studies cited, while recognizing that trans, non-binary and intersex people are also affected by this issue.)
The panel’s recommendations intensify a debate that has been brewing about who might benefit from the treatment. Some clinicians say that most men with low testosterone, especially young ones with no medical issue contributing to the problem, don’t need supplemental treatment at all and should be able to raise their testosterone levels by adopting a healthier lifestyle and losing weight. Others argue that men with low testosterone who have symptoms such as low libido, fatigue and irritability could gain from the therapy.
More-enthusiastic proponents, including many members of the FDA panel at the December meeting, take a third view: that all cis men should be tested, and those with low testosterone levels should be treated even if they have no symptoms. “You could make a very strong argument that having a normal testosterone level is important for health and prevention of illness,” says Abraham Morgentaler, a urologist at Harvard Medical School in Boston, Massachusetts, who took part in the December panel.
Morgentaler and other panellists stressed at the meeting that testosterone is not just a ‘lifestyle drug’ that men take to build muscle and feel good. Yet it is increasingly being marketed that way. Podcasters such as Joe Rogan and his guests have sung the hormone’s praises. And scores of testosterone clinics are popping up around the world1, promising fitter bodies and a boost in energy levels to people who might not even have low testosterone to begin with.
At high doses, testosterone use potentially comes with risks ranging from infertility to increased mortality. The drug is currently classified as a controlled substance with potential for abuse in the United States and several other countries, owing in part to doping scandals in the 1990s and 2000s. That classification is worth reconsidering according to statements made by FDA commissioner Marty Makary, who also voiced his enthusiasm for testosterone at the December panel.
So what is the evidence for the safety and benefits of testosterone replacement?
Read the full article: Testosterone therapy is trending. Who really needs it, and why? (Nature)
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As Matt Kaeberlein says… in his Optispan podcast… TRT is one of the biggest game changers for him, in health benefits.
I have used for 6 years… weekly injections. I concur!
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