Source: https://x.com/BioavailableNd/status/1980978014532833522
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Hi
Yes I’d be interested in your results. My partner is considering options at 70…
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I don’t have access to X. But I think they’re talking about this 2012 study published in an unknown Iraqi medical journal:
https://mjtu.tu.edu.iq/index.php/mjtu/article/view/539
322-329.pdf (1.7 MB)
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Hmmm… more Ginger Ale please. And, a bit of Jameson Scotch with lime. My go to bar drink.
Ever try backloading insulin syringe with T using 5/16/8mm pin for subQ?
Works better for me although it adds a step and more waste.
I have not. I think the injection site reactions came from not having the needle deep enough in the muscle.
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Understood.
FWIW I’ve done both methods.
Ive had much less reaction using insulin pins as opposed to IM.
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I do not recommend Purerawz.co as a supplier. I have placed several orders with them, but my most recent order was shorted. I initiated a documented email trail explaining the issue and complied with all stated customer service requirements to have the missing product shipped. However, despite multiple follow-up emails, it appears that the customer service representative has lost track of the prior correspondence.
They do not seem to have any effective system for tracking or resolving customer complaints to completion. Once payment has been received, there appears to be little concern for post-sale problem resolution.
I also reviewed Reddit and found several discussions reporting similar negative experiences related to order issues.
Well, if you know of a similar company with a good reputation when it comes to customer complaints let me know.
As a general statement, it should be pointed out that when you check your testosterone level, you should ask for the gold standard Testosterone LC/MS and not the standard immunoassay which can easily be falsely elevated if you’re taking HCG, other androgens, and a few other things. Might as well make sure you get the most accurate test because it really does make a difference.
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Here’s a concise summary of the most important points from that long video transcript about how testosterone metabolites work and why they matter:
• Testosterone is a pro-hormone that gets converted into many downstream metabolites beyond just estradiol (E2) and dihydrotestosterone (DHT). Those metabolites often have distinct biological effects that influence mood, body composition, cognition, immune function, vascular function, and more.
• The common notion that “it’s just testosterone, DHT, and E2” is oversimplified. In reality, testosterone’s metabolism continues far beyond those two pathways, creating many compounds that are biologically active or locally important to tissues.
• DHT itself is only one part of the story. For example, 5-beta DHT and its metabolites don’t bind the androgen receptor but instead appear to support vascular health and nitric oxide-mediated vasodilation, separate from androgenic signaling. Blocking enzymes that produce these can have unintended effects.
• Certain metabolites have neuromodulatory roles. Some act as neurosteroids that influence GABAergic signaling, anxiety, cognition, and memory, while others affect immune responses (like fever induction) by interacting with immune pathways.
• Estradiol and its metabolites are similarly complex. Some downstream estrogen metabolites appear more potent than E2 itself at specific functions like inhibiting inflammatory adhesion molecules that contribute to atherosclerosis or acting as neuroprotective agents.
• The effects of enzyme inhibitors (such as aromatase inhibitors for estrogen or 5-alpha reductase inhibitors for DHT) are not limited to changes in E2 or DHT levels. They can alter levels of multiple metabolites with unpredictable downstream effects because these pathways are interconnected and locally regulated.
• Tissue levels of metabolites often do not correlate with serum levels, so measuring serum hormone concentrations alone can give an incomplete picture of metabolic activity in tissues like brain, vascular endothelium, or prostate.
• Some metabolites may explain clinical phenomena like “steroid flu,” altered fat distribution, or adverse symptoms with drugs like finasteride because they influence pathways far downstream of the initial hormone.
• Overall, the steroid hormone network is highly complex and finely tuned, and simplistic approaches to manipulating testosterone or its downstream products can disrupt important physiological functions.
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