I wonder if this is just a random observation by the OP.
In my experience I’ve found that unlike rapamycin, fasting barely every causes aphtous ulcers or skin infections.
So i sometimes do lower rapa + fasting instead of high rapa.
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I would really like to add extended fasting to my current 24 hr daily fasting, but I am SO paranoid about loosing extremely hard earned skeletal muscle. There are studies indicating muscle strength is more important for mortality, but I’d like to keep my skeletal mass reserve into older age, thank you.
Is muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations
10 day fast, 16 men
“Lean soft tissues (LST) accounted for about 60% of weight loss, 3.53kg (almost 8 lbs). LST loss was explained by the reduction in extracellular water (44%), muscle and liver glycogen and associated water (14%), and metabolic active lean tissue (42%).”
60% x 42% = 25% absolute weight loss due to metabolic active lean tissue.
“Muscle function was maintained or improved, suggesting that changes in protein breakdown did not negatively impact muscle function in this context. Importantly, because our fasting protocol included daily physical activity, we are unable to evaluate the impact of fasting per se on muscle strength and performance”
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Consider extending the full fast by following it with a fast-mimicking diet. In five years of doing 5-day FMDs (about 10 times/year), I’ve never had a noticeable muscle-loss issues on the FMD, and I’m moderately muscular.
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Whenever I’ve done a 3 day water only fast, I just stop doing the cardio but carry on with the usual weight training. Never noticed any loss of strength on the next workout post restarting to eat.
I have not noticed any loss after a 3 day fast either. Peter Attia makes sure to lift when fasting, to “tell the body” that it needs to preserve the muscle
My strategy is to shut down IGF-1 as much as possible during fasts, so I exercise minimally. This preps the body for regrowth during refeeding. In his research, Walter Longo has found that activating IGF-1 during the fast stops the stem cells from being activated for tissue regeneration during refeeding.
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I began fasting by utilizing time restrictive feeding and then progressing to the Prolon system for 5 days. The food included is nothing that will elevate insulin and honestly, tastes pretty mediocre but it got me over the hump. After 6 months of monthly use, I found that my metabolism had gained flexibility and I constantly had food left over at the end of the fast. At that point, I just decided to stop buying the kit and drink nothing but coffee, tea, water, and electrolytes such as LMNT. Now fasting is a breeze and I haven’t noticed much difference when I’m taking Rapa.
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I also became adapted to the FMDs after a number of cycles, finding them easier as time went by.
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I’ll be starting a 3 day water fast in 1 hour. I usually take my rapamycin (6mg) in 15 hours on a Saturday, so I’ll take half that dose while fasting (3mg). Hopefully it helps inhibit mtor more & increases autophagy.
Won’t take my full dose of rapamycin while fasting as I read around online that it can cause mouth ulcers etc when combined with water fasting as mentioned above on this thread.
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I am going to do a five day prolon fast with rapamycin next month. I haven’t done one since I started. I have to admit that the water-only fasts are easier and cheaper but I have several of these kits.
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