Stress and Aging - Dose / Response and Permanence?

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A reasonably good summary of the state of things:

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One thing I have noticed from my stack is that I am much more tolerant to stress and anxiety. I can keep my cool a heck of a lot better nowadays.

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My own experience says it’s mainly the lithium. :slightly_smiling_face:

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I think you are correct. It’s amazing what lithium does. I love it!

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https://player.fm/series/unexplainable-2890259/stress-ages-us-on-a-cellular-level

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Paper: https://www.sciencedirect.com/science/article/pii/S030645302200292X?via%3Dihub

Source: https://x.com/MitoPsychoBio/status/2039739832985915403?s=20

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All the more reason to chill and relax. :slight_smile:

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Psychological Stress as a Risk Factor for Cardiovascular Disease: A Case-Control Study

Paper: Psychological Stress as a Risk Factor for Cardiovascular Disease: A Case-Control Study - PMC

Association of Low‐Density Lipoprotein Cholesterol Levels with More than 20‐Year Risk of Cardiovascular and All‐Cause Mortality in the General Population

Paper: https://www.ahajournals.org/doi/10.1161/JAHA.121.023690

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“ …Because we have a finite energy budget….”

Maybe finite (vs infinite) but not fixed / unchangeable. Build mitochondria to increase the energy budget. Exercise is good for a lot of things.

I do not see how any assertions in that tweet can be derived from the linked studies.

Published in 2020 (‘New research suggests…’ :face_vomiting:)

Six month single site observational study of a hundred Afghans with cardio events that brought them to the hospital, with the family/friends/caregivers that accompanied them used as controls. No adjustments for… anything. Based on a questionnaire filled out after the event.

This is the money quote from the second study (which is from 2022): Summarized - ‘LDL > 100 healthier than LDL <70’.

After adjustment for age, sex, race and ethnicity, education, socioeconomic status, lifestyle factors, C‐reactive protein, body mass index, and other cardiovascular risk factors, individuals with LDL‐C<70 mg/dL, compared to those with LDL‐C 100–129.9 mg/dL, had HRs of 1.45 (95% CI, 1.10–1.93) for all‐cause mortality, 1.60 (95% CI, 1.01–2.54) for CVD mortality, and 4.04 (95% CI, 1.83–8.89) for stroke‐specific mortality, but no increased risk of coronary heart disease mortality.

Looks like the ACC/AHA need to revise their new guidelines.

https://www.ahajournals.org/doi/10.1161/JAHA.121.023690

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