Staying Up to Date with COVID-19 Vaccines | CDC 2024-2025

#124

Obviously an n of 1 proves nothing, but like all singular and extreme cases it can often be a fruitful source of inquiry. A lot of progress in science has been achieved by understanding the exceptions. So I’m glad his case was written up, maybe some science can come of it.

My unscientific musings in this case were that it’s notable that he’s just a random guy. It’s not the case that an individual was selected, or selected himself that is exceptional in respect to vaccine reaction. He’s a random guy. If he were a one in a million vaccine tolerant freak, then you could say, “217 shots, yeah, one in a million physiology”, and ignore his case, but no, he was a random guy, since what are the odds that the 217 shots fell on just the “one in a million” guy (actually, odds are one in a million, by definition, heh).

So, you pull a random guy out of a crowd, and you shoot him 217 times with covid vacc and zero negative effect. That tells me that a random person - perhaps you or me - can potentially take at least 217 covid shots and be none the worse for the wear. I find that thought encouraging as I contemplate the possible risks of taking the covid vaccine a couple of times a year. Not some profound proof of anything, but a cheerful tidbit as I’m about to roll up my sleeve later today. YMMV.

#125

What was the administered dose of Metformin? Didn’t see it in the article

#126

“Metformin; immediate release formation; 500mg on Day 1; 500mg BID on Day 2 through Day 5; 500mg in AM and 1,000mg in PM on Day 6 through Day 14.”

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#127

Corruption, cover-ups, politics, money, poor studies, denial.

I still find it laughable that so many people touting the effectiveness of the COVID-19 vaccine have caught COVID-19, not just once but several times.

I will never forgive or forget the forced mandates. The lockdowns. The supply chain breakdowns, the blatant lying, fudged statistics, etc
A whole generation of kids has probably been given the handicap of missing school when they were not likely to get it or if they did it would be a mild case.

The blatant lying in the beginning when the drug companies and Fauci were telling us that the Covid-19 vaccine was 90% effective in preventing COVID-19. Telling us masks were effective, certainly not the cheap Chinese masks that everyone was wearing.

If nothing were done, as witnessed by several countries, we would have been better off.

The tyranny of big government and big pharma was on full display.

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#128

I thought Twitter/X was the place for right-wing conspiracy talking points.

#129

How come all those conspiracies come true lol

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#131

Well that’s all the proof I need! Anecdotes ftw!

BTW, the vaccines were 90% effective in the beginning before the virus mutated. It continues to mutate. Do you understand that?

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#132

I had two Pfizer vaccines at the beginning, with 4 mo interval between them. Had Covid once (mild form). I was wearing quality masks when inside all the time.

My friends, a married couple, didn’t vaccinate at all, and didn’t wear masks - they both had Covid at least 6 times. They are constantly sick now.

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#133

I agree - Covid (pro or against) has become a bit of a religious argument.

Personally, I don’t think its worth the time to discuss it anymore. And most of the people here are very fit and healthy (with good Rapamycin-boosted immune systems), so its probably not a big risk factor either.

I think I’m going to lock this post soon as it seems to be going in circles.

Move along people, nothing to see here. :slight_smile:

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#134

I didn’t catch the study. Do you think you can do the same with XR? (Meaning, maybe IR just happened to be what they studied?)

#135

My wife and I just got the covid and flu shots, she already claims to feel uder the weather… it’s been three hours, so I suggested maybe a nocebo effect. I as per usual feel no side effects, but we’ll see over the next couple of days. We got our shots at a pharmacy chain, a busy part of Los Angeles, and we were the only folks getting any vaccines. I sense there’s probably little uptake of this version, considering it’s already a generation or two behind the most prevalent strain of virus at this time in SoCal.

#136

Two years of health issues after one Pfizer. Then got RSV and Covid and more random symptoms loss of smell, hair loss, joint and nerve pain- am a year out and still get costochondritis, brain fog, sensitivities to products -latest being toothpaste etc etc. I belong to long covid group and most are vax injured - with very similar symptoms to covid. Viral persistance. Will never get anothert vax.

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#139

Less politics, more science: Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals 2024

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Press release: Multipurpose Vaccine Shows New Promise in the Presence of Pre-Existing Immunity

Viruses like SARS-CoV-2, including the virus that caused the original SARS epidemic in 2002, belong to a family called SARS-like betacoronaviruses, or sarbecoviruses.
After receiving a vaccine against SARS-CoV-2, the body makes many different antibodies that target different regions of the virus. Some of these regions, known as conserved regions, are identical between variants. Antibodies that target conserved regions are more likely to protect against multiple different variants and similar viruses.
The mosaic-8 vaccine is designed to elicit antibodies against conserved features of sarbecoviruses.
Mosaic-8 Produces Broadly Protective Antibodies Regardless of Prior Exposure or Vaccination
“Current COVID-19 vaccines are not specifically designed to generate a broad antibody response that could offer better protection against variants or related viruses,” says postdoctoral scholar Alexander Cohen, a co-first author of the new study. “We developed a vaccine to give broad protection against a spectrum of sarbecoviruses in order to prevent the next pandemic. Fortunately, our new results show that this vaccine functions as designed to elicit broadly protective antibody responses in both previously exposed and immunologically naive animals.”
Phase 1 clinical trials to test the mosaic-8 vaccine in humans are scheduled to begin in 2025.

This shows that:

  1. The current “updated” boosters are weak
  2. We potentially have a better solution
  3. This better solution will follow the usual R&D and regulatory pathway and will hopefully convince everyone

Unfortunately, we’ll have to wait a few more years :slight_smile:

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#140

Did you also had an RSV vaccine? I’m considering to get it this fall.

#141

“. . . those who were not vaccinated were substantially more likely to die.”

Source: Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine — Oregon, June 2021–December 2022 | MMWR

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#142

Agreed, we need vaccines that address the conserved regions of viruses/bacteria, otherwise you’re always chasing the last generation and the effectiveness is drastically diminished - look at the farce of flu vaccines, always a day late and a dollar short. Universal vaccine against all strains, universal flu, universal covid, universal cold and so on!

In fact, I felt a bit silly yesterday getting a covid vaccine that focused on the previous, almost irrelevant strain of the virus, while FLiRT is raging here in SoCal at levels close to the height of the pandemic; it does seem somewhat milder in the symptoms, FWIW.

But personally, the immediate symptoms of covid were always irrelevant. So what, you have two or five bad days, meh. No, my worry has always been the long term effect of the virus in the body, the penetration of various tissues, the heart, brain, lungs etc., with long term persistense and resultant pathologies; there appear to be quite a few reports of neurodegeneration, even Alzheimer’s like effects. And this has nothing to do with how severe the initial symptoms are. The mere fact of exposure is what allows the virus to attack your body long term. You may have zero symptoms, but have the virus long term.

Which is why I do try to stay as safe as I know how to, mask up in higher exposure areas (how are laws against masking constitutional?!), and get vaccinated regularly, even if the vaccines are somewhat subpar - I figure every little bit helps.

However as always, to each their own. I don’t think there should be mandates for or against. Everyone is responsible for their own choices, and should be free to do so. I report and explain my choices, and am interested in your choices, especially if they are different - that’s how we learn. What I am DEFINITELT NOT interested in is haranguing people, or condemning someone for their choices, whatever they may be. Tell me what you’re doing and why, and I’ll do the same, that’s the purpose here, seems to me, an exchange of information.

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#143

My doc advised me against RSV last year (but I’m not 60 either)…

I think I’ve heard some negative things about it recently… do double check

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#144

I’m in your camp, fwiw, perhaps it’s because we are both in CA. I think our outlooks are often regional. For instance, I get on a plane in CA and there are rows of masks, and then I get on a plane in NYC and there are two :slight_smile:

I just got vaxxed yesterday to prep for my trip to LA in two weeks, because yes, everyone around here seems to have it now! I thought this new vax was for the current strain, ooops.

And for anyone interested… I normally get clobbered by the vaccines… aside from a tender arm, I can’t tell I had it… this is a first.

#145

I’m sorry you went through and are continuing to go through this.

My friend got guillaine barre from the first vax, so naturally he never got another one… but every time he gets covid (aprox 3 -4 times), he’s VERY sick for aprox 3 weeks. And even remains positive for well over 2 weeks. Others than this, he is a seemingly healthy guy, under 60yo. This is just one person and means nothing, but I do wonder if there are just some people who aren’t going to do well with the vax OR actual covid. I don’t understand it well enough.

Again, I’m sorry for what you are going through and I hope they eventually figure out how to help you and people with long covid.

#146

Thanks Beth! I’m also a little hesitant to have it. It’s usually recommended for 75+ population, and in rare cases can trigger serious side effects. Will get a flu shot for sure sometime in October.

1 Like