Startup selling Klotho peptides (apparently)

[One]

Thanks for sharing.

Some of these, like Klotho, rely so much on hypothetical benefits that I can see that.

There does seem to be a wave of podcasts and email newsletters starting to hype it up again (from “Hunter Williams” at one end of the spectrum to Dr. David Barzilai (@aging doc on X) at the other end) which makes me think that either they have figured out a source to sell more of it or there is some study/publication about to come out on Klotho.

[DrT]

I believe that the benefits of elevated Klotho are real.
The problem seems to be that exogenous (injected) klotho is so rapidly cleared from the body that it is doubtful it has time to initiate changes. You would need to inject large amounts every day.

The solution seems to be either to work on boosting your own production of klotho, or use a genetic modification to increase expression of klotho. I don’t know of any lab or company offering the latter.

I have Dr Fraser to thank for sharing his pioneering work in klotho.

[Steve_Combi]

@DrT

genetic modification to increase expression of klotho

Liz Parrish and one of her partners have done this and I think they offer it.

Liz Parrish klotho genetic mod.pdf (280.7 KB)

[Satchel]

Actually the short half life of Klotho is immaterial. It is the PF4 activation that occurs immediately after klotho administration that is important. (For cognitive effects) unknown for whether klotho half life is important for the overall reduction in MACE

[Olafurpall]

@Beth

I still thought, well, as with many other things, perhaps some is better than nothing, but amongst all of the smart and proactive people here, almost no one uses it. I then asked around in the facebook Klotho group, and almost no one there uses it there either.

With all of that combined, I stopped buying it in fear of it being a waste of money.

It still makes sense to me that a little is better than nothing, but if that were true, I’d think more people here might be using it, so I’m just assuming I’m wrong. I do wonder if more people would use it in small doses if it were more affordable, or if everyone simply thinks it’s a waste of time.

I think the main reasons many people don’t use Klotho, aside from the fact that it isn’t so well known, is the fact that it’s hard to get hold of it and that it requires injection. Only a very small minority of people ever use things that aren’t approved as supplements or drugs or require injections.

Personally I’ve been aware of klotho being potentially beneficial for aging since long before people started experimented with it. My cautious approach has been to simply try indirectly supporting endogenous Klotho production.

[touringsedan]

Jay Campbell is selling Alpha Klotho with modifications to extend half life. I doubt it is real or safe and I regard Jay as one of the worst humans in the peptide space. But here is the link for the curious. I would love to know if it can get tested and if anyone can find an Assay for testing it to confirm it is working.

Klotho Peptide (a-Klotho MAB) 10mcg - 99% Purity, Third-Party Tested

[Beth]

That’s good feedback, thanks.

I’d normally never jump on anything almost no one is doing, but I felt comfortable trying klotho simply I was advised by a smart doc and Peter Attia and Tim Ferris have said they are about to be guinea pigs in a trial (which to me says they already take it but who knows)

I am curious about so many peptides, but I have only experimented with NAD, glp1, and klotho. I am ordering SS-31 now (felt comfortable after rapadmin met the researcher), and I might add TA-1 to my order to have on hand incase I get sick (really, adding TA-1 it all about getting free shipping because I’m a sucker for that, so I’m still googling to see if there are any potential downsides).

@touringsedan there is a klotho test one can take. If I recall, it might be $300 or so? (Grain of salt on that $) . I definitely don’t have the stomach to test out a new form on myself.

[Ashimane]

Thank you Beth for your insight. I too have been on Klotho once a day for a couple of years. Recently Ive really started questioning why I’m doing it! So expensive with untestable results. I am also ordering SS-31. I look forward to hearing about how it works out for us older folks.

[curt504]

Just a few cents of comments re klotho supplementation.

There’s only a few researcher principals in this mfgering/research space IMO. And a few fragment versions each with probably different effect and efficacy.

Dr Alex Grinberg: https://www.youtube.com/watch?v=1sjloIomcTE&t=268s
Fiona Chin is a AU kidney clinician who takes klotho for her on CKD/autoimune issues and is in the private health group: TPC ARMY , $200/mo.

We are very early in this space!! Human klotho is a large molecule and the versions available for sale are fragments. Much like many peptides are fragments of the natural version.

Biolongevity labs is one fragment that was modified with albumen to some how have 2 week half life, II think called klotho-a (??). Another version that Fiona/Geinberg are working with I think is called Klotho-1 and is taken daily at 100mcg to 300mcg daily. Cost via the TPC group is cheaper for more daily doses vs the biolongevity labs version maybe a bit cheaper for longer time span that the $$ buys. I got my klotho-1 this week but won’t take a first dose till next week for travel reasons. BLL’s didn’t move my wifes or my needle at 72yo / healthy.

Only rumor; FOX03 also in the same biological pathway that klotho facilitates is being worked on as a suppliment. No time frame, just said that it’s desired to have that one too available for “research”.

The days when we got on TRT even HGH to advance our longevity are way way way behind us. I will say though, re klotho; 1st hand info from a few folks like Fiona, indicate that for some, often sick, klotho really moves the needle. So far for me; and re klotho-a, not.

Good luck experimenting, curt