Thank you all. I will try the boron but realistically i think i need to lay off of heavy lifting which is very hard for since i have been doing it for so long. I think i just need to do more cardio.
My problem is mostly severe tension in my neck rather than pain.
The diffculties with Stem cells is twofold. Firstly you need the stem cells, but then you also need them to differentiate properly. The first part is I think a mainly HIF 1 alpha thing where a stimulus to create stem cells is required. The differentiation problem is a DNA transcription issue. If you take an injection of stem cells that does not guarantee that they will differentiate properly.
Lower weights, more reps.
We arenāt mice ā¦ and it looks like little evidence for this once disease is established ā¦ which is why it is important to do things to slow aging before there are symptoms ā¦ but still an interesting study. There are multiple āhopefulā studies of Dasatinib and Quercetin in people for senolytic effects using 3 days of Dasatinib at 100 mg daily with Quercetin 1000-1250 mg daily. I know Dr. Alan Green does it with both Quercetin and Fisetin. We have some human trials - not sure it is ready for prime time - but I know there are people doing this combination on this platform, and wonder if they have had any positive effects on degenerative disc disease or their chronic back/neck pain? The study however is interesting, and suspect it would be roughly equivalent to a human doing this regimen every 6 months.
Would love some thoughts, especially from those who are taking this combination.
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I think the senolytic effect (or senomorphic) can be measured by the normal levels of CRP. That is the levels of CRP when there has not been a recent infection. Measuring this, however, requires multiple measurements over a period of weeks. I am currently going through the effects of Covid which drove my CRP right up and I will know when it drops to its usual ātoo low to measureā value. This I think will probably take 4 weeks from the end of the infection.
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CRP is an interesting test, I utilize it 4-5 times daily in the ER. The issue is that there are 100+ items that can increase its level. It takes ~14 hrs to increase after some type of infectious/inflammatory insult begins, and will often continue to rise for days after, as long as the issue remains. Once the issue resolves or is improving, it has a metabolic half life of ~20 hrs. So once the issue raising it has resolved, it really should be down at a reasonable level in 7 days.
We interestingly got bit by this a little bit by an unexpected issue that elevated ours when we did our Inside Tracker labs 6 months ago. We figured weād have awesome results with doing a virtual mimicking fast (Prolon - Dr. Longo) leading into it. So next thing my WBCās normally 4-5 were 14, my lymphocyte/neutrophil ratio went totally horrible and my CRP which is usually 0.3 went to 7 or 8.
Interestingly, it seems like the first day or two of the fast, youāll get a decrease in CRP/WBCs then you get some type of inflammatory response and the levels go up.
I guess the thing Iād say is that part of having a senolytic protocol like Dasatinib/Quercetin, which seems remarkably potent, is that youāll have some type of inflammatory response with the clean up of defective cells, and Iād be surprised if the CRP doesnāt go up substantially acutely, then settles down to a lower level come 7-10 days after the effect has ended.
Iād be interested if anyone has actually tested and has their own experience in this setting.
I still donāt hear from anyone who has done this protocol, or regularly does this in regard to the spinal symptoms.
We arenāt likely to get human trials on this any time soon, and the best weāll know is anecdotes, which are interesting, but not science, - but still interesting.
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I have weekly CRP figures.
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