Thanks so much for sharing such detailed info, Bruce. I really appreciate. I hope your pain/arthritic problems will stay away. You surely have been thinking out of the box, and it’s fantastic to read it worked so well for you. Exosomes do look very promising.
Be careful with first choice. Their product was randomly tested and found to have 1/5 labeled dose.
I have used Pentosan for nearly 2 years with great benefit for my knee. Purchased Pentorse brand through Indian pharmacy, I used Parth Medical, $80 per vial, shipping is high because they ship with ice packs.
It is also available through compound pharmacies if you have a prescriber who is associated with one.
I have been reluctant to try the oral because of the vision side efects. Ii have had no problem and good benefit with the pentosan sub-q, as long as it is truly sub-q, otherwise can burn if not in the sweet spot.
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$20 Pill vs $20,000 Surgery? Popular Diabetes Drug Metformin Found To Relieve Osteoarthritis Knee Pain
Metformin may reduce knee pain in overweight patients with osteoarthritis, offering a low-cost alternative to early knee replacement surgery, according to a Monash University trial.
A widely used diabetes medication may help relieve knee osteoarthritis (OA) pain in people who are overweight or obese, potentially delaying the need for knee replacement surgery, according to new research led by Monash University.
The study, published in JAMA, investigated the effects of metformin, a drug commonly prescribed for type 2 diabetes, on knee pain. Over a six-month period, researchers conducted a randomized clinical trial comparing metformin to a placebo in adults with symptomatic knee OA and no history of diabetes.
Conducted entirely via telehealth, the community-based trial enrolled 107 participants (73 women and 34 men) with an average age of 60. Participants received either a daily dose of up to 2000 mg of metformin or a placebo. None had diabetes.
Measured Impact on Pain Levels
Knee pain was measured on a 0-100 scale, with 100 being the worst. The metformin group reported a 31.3 point reduction in pain after six months, compared to 18.9 for the placebo group. This was considered a moderate effect on pain.
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FWIW.
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Three papers on Pentosan Polysulfat;
Clinical Trial
“The effect of pentosan polysulfate sodium for improving dyslipidaemia and knee pain in people with knee osteoarthritis: A pilot study”
https://www.sciencedirect.com/science/article/pii/S2665913123000109
“The interaction of pentosan polysulphate (SP54) with human neutrophil elastase and connective tissue matrix components”
https://www.sciencedirect.com/science/article/abs/pii/0009279783901552
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