SGLT2 Inhibitor Canagliflozin eliminates senescent cells and alleviates pathological aging (in mice)

[A_User]

I don’t know if I’m not an expert… I can think of situations where there can be cyclical effects from gene variants. There’s no spin, just a response to your question.

If you can’t find MR or RCT’s then maybe you don’t have enough evidence unless you think the expected benefit outweighs the risks. I’m not going to look or investigate all of those +EV bets if they are small as that’s too much cognitive load… Pascal’s Mugging Spam. And why I tune out from anyone or any studies using a bunch of buzzwords.

[Neo]

@A_User

I can think of situations where there can be cyclical effects from gene variants

But the MR could not capture that at that level

[Neo]

Thx @adssx . Well try and read the paper when things slow down a bit for me.

[Neo]

Can turn it on so you can accept DM messages, tried to send you one but it did not go through because not accepted

[Neo]

@A_User

[Lee_Piercy]

Hello, I have been researching the various ‘reliable’ larger pharmacies in India shared on this site and sent several emails to a few of them requesting price and product quality verification. However, thw casual way they responded still makes me a little nervous about taking the plunge. Not concerned with not getting the product but even with branded products like empa worried it’s not the real branded product. Can you share whom you have had a positive first hand experience with please. Thanks!

[DeStrider]

I have had positive experiences with Jagdish Nikose and Maulik. Both have provided extremely good quality and value. I have used both several times.

Here are their WhatsApp contacts

[Lee_Piercy]

Thanks a lot. Much appreciated

[Hackingbiology.com]

How about dosing of mg/kg on humans, outside of standard on-label uses?

I take it 100mg, and general onlabel uses is:

“100 mg PO daily taken before first meal of the day. May increase dose to 300 mg daily if 100 mg/day tolerated in patients who have eGFR ≥60 mL/min…”

So my take is what would be a dosing to have senescence-cleaning effect in human?

Anyway be sure to wash your penis more often when you pee, as there’s a 4-fold increase of fungus and infections due to increase of glucose in urine.

Fabio