RMR = Robust Mouse Rejuvenation by Aubrey de Grey Update Xmas 2023: rapamycin works the best
Could anyone explain the other three treatments besides Rapamycin?
Ah. Conjugated Navitoclax as a senolytic. Brilliant.
Here’s an interview with more details on strategy and compounds used.
Aubreydegrey just shared the initial results of combining multiple known longevity interventions, and the results are epic. In the control group (blue), only 35% of the mice are still alive. Meanwhile, in the group that received all the interventions (red), close to 80% are still alive.
aubreydegrey: Everyone please note that this is just females. The survival of control males is over 60% at present, so the average is just on 50%, as expected for C57Bl/6 of this age. (This strain is well known to be unusual in that males outlive females.)
One of the most exciting things about this study is the fact that the interventions stack. I hope these will become available for humans in the near future as well.
Yes, the other treatments are
Mouse telomerase reverse transcriptase
The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5(+)) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating...
And Nav-gal, a senolytic
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer...
If I’m reading the chart correctly, together they outperform rapamycin?
But the other two are not fit for humans yet, I believe. So, only Rapamycin is viable for us right now. D+Q might be a decent substitute for NavGal.
D+Q = Dasatinib + Quercetin?
Regarding the stacking of interventions in the above plot, less than 10% added on top of rapamycin effect for males, for females higher.
I thought there also was a stem cell treatment via reduced conditioning method. Is that no longer a part of it?
Yes - HSC (hematopoietic stem cells). see this thread:
Robust Mouse Rejuvenation Project - #12 by RapAdmin
@L_Hayes @DeStrider and others here is more info on that - seem very promising as it is not just one new type of small molecule, but represents a new class of longevity treatments (and is one example of the power of “replacement”
And there is what look like a robust study, by a separate and good group in a good journal showing longevity benefits of HSCs that I had missed
… done without radiation or other toxic ways to prorate for them
Haven’t look at the paper carefully yet, but find it very exciting
Interestingly these results are in female mice even if they expect the effects to be larger in males
With age, stem cells diminish in their ability to regenerate adult tissues, likely contributing to age-related morbidity. Thus, we replaced aged hematopoietic stem cells (HSCs) with young-donor HSCs using a novel mobilization-enabled hematopoietic stem cell transplantation (HSCT) technology as an alternative to the highly toxic conditioning regimens used in conventional HSCT. Using this approach, we are the first to report an increase in median lifespan (12%) and a decrease in overall mortality hazard (HR: 0.42, CI: 0.273–0.638) in aged mice following transplantation of young-donor HSC…