I did and the increased HR seemed the same on both + 10-13.
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I’ve used tirzepatide for a while and I’ve not noticed increased heart rate. I’ve been curious to try reta but I’ve been hesitant because of the HR issue.
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I have been on tirzepatide for 1.5 yrs, 5-6mgs, and it has a severe affect on my emotional health. Definitely depressive and a lack of motivation for 4 days after injection. Are there differences between the GLP’s with regard to mental isssues?
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I was curious so I just entered this question into perplexity
If I were you, I’d experiment with the others just to be sure
Tirzepatide‑associated mood changes suggest a possible class vulnerability to GLP‑1–based drugs, but cross‑reactivity is not guaranteed and data are still mixed and low quality. Some people worsen on one GLP‑1/GIP or GLP‑1 agonist yet tolerate another, while others seem sensitive to the whole class, especially if there is underlying mood vulnerability.
What is known so far
- Post‑marketing data and pharmacovigilance studies have linked semaglutide, liraglutide, and tirzepatide with reports of depression, anxiety, and suicidal ideation, but true causality and absolute risk remain unclear.
- Regulatory reviews (FDA, EMA and recent cohort studies) have not shown a consistent, definitive increase in suicidality signal overall, although some observational analyses suggest higher rates of depressive disorders and suicidality in GLP‑1RA users compared with some comparators.
Class effect vs drug‑specific risk
- Some large datasets show an increased risk of major depression, anxiety, and suicidal behavior with GLP‑1 receptor agonists as a group, suggesting at least some class‑levelassociation in susceptible patients.
- Other analyses and real‑world cohorts show neutral or even lower suicidality risk with tirzepatide relative to other anti‑obesity medications, indicating that risk may differ by molecule, dose, indication, and patient population.
Individual susceptibility
- Reviews and case‑series emphasize that psychiatric adverse events are rare overall but appear more likely in people with pre‑existing mood disorders, a strong personal or family history of depression/suicidality, or rapid weight‑loss–related psychological stress.
- There are also reports of improved mood, anxiety, and binge‑eating symptoms on tirzepatide and other GLP‑1s, suggesting heterogeneous CNS effects that might depend on baseline neurobiology and genetics.
Practical implication for your question
- If tirzepatide clearly precipitated new‑onset or markedly worsened depression temporally (onset after starting, improvement after stopping), there is a non‑trivial chance you could react similarly to other GLP‑1 drugs, so any re‑challenge (even with a different GLP‑1) should be done cautiously with close psychiatric monitoring.
- However, a prior depressive reaction to tirzepatide does not prove that every other GLP‑1 (e.g., low‑dose semaglutide, liraglutide) will automatically cause the same effect; some clinicians will consider a different agent at very low dose with slow titration if benefits are compelling and you are co‑managed by a mental‑health professional.
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Semaglutide is worse.
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did you try retatrutide - are its mental effects the same? I read somewhere that retatrutide had different effects on the brain compared to semaglutatide and tirzep
I have not tried it. I’ve used semaglutide and then swapped to tirzepatide.
I prefer tirzepatide.
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What is a good Chinese supplier to get Reta from these days?
Ever since SSA went down it has been very confusing.
Thanks. These guys have been around a while I’ve seen their names.
So you use their peptides?
yes, theirs and another 10 others… everyone is the same until one of them screws up and then you’d hear it. .
Yep, my very first order was from him… I got half of it and then he went dark …
he is not dark now…
Thanks, yes, I do realize. I’m not even opposed to ordering from him, but if all else is equal, I would personally choose someone else until he makes an attempt to make people whole again (mine was a tiny order and I don’t really care and I don’t foresee ever getting my missing kit, but it just casts a shadow on him and I wouldn’t want someone else ordering from him thinking nothing has ever gone wrong)
There are ways he could show some character without digging deep into his pockets making people whole… for example, if you were stiffed, I’ll give you a 10% discount on your order, etc… just many ways he could do it while still profiting
to me past is past and I don’t dwell on it. Almost everyone will at some point get stiffed one way or the other in the gray market. Just the nature of the beast, so to me if he has what I’m looking for and has it at a reasonable price, I wouldn’t hesitate to buy from him. As for him making someone whole on orders pre dark I totally doubt. I just happened to be lucky and asked for a refund, and he refunded me literally 3 days before he went dark. Even if I lost that money not the end of the world. I expect to lose at some point anyway. It is just my luck that it has not happened yet.
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Totally agree, and I am not upset about my loss and wasn’t even when it happened.
I would definitely buy from him and I’ve given him as a quality source to some people, but my point in sharing was to only make the unsuspecting aware that if things go south, he probably won’t take care of them.
I just have empathy for the many people who can’t easily lose $100 or more.
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Personally I’d prefer a vendor who hasn’t unapologetically ripped off hundreds/thousands of customers and is now making money again without making amends, but that’s just me.
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Understood and it makes sense on most cases. Not so much with the gray area. They are operating in very turbulent waters, and we wouldn’t know the real reasons why they go dark. who knows they might have lost their shirts in legal/fines fees and have no way of making good on anything. Plus, the dude claiming now to be Tracy is behaving nothing like the old one. For what you and I know it could be someone related to him/them and the real one that stiffed people might be sitting in a nice cell somewhere.
Exactly @Davin8r. He is making such a marketing mistake. If he just made a little effort, he’d have so many more customers…
If I were his marketing consultant, it would go something like this…
‘you’ve had a loss and I can’t afford to pay everyone back yet, but because I am so grateful you are willing to give me another chance, I want to thank you for your loyalty and I’ll give you x % off all your orders until you are paid back… the % could be a sliding scale depending on how much you lost. Higher % after he has had a chance to recoup some losses… etc etc.
That gesture would be worth enough good will that his offered discounts would be paid back to him in spades… but he has not asked me yet 
If the same happened to PGB, I feel they would do better.
@Kelman interesting theory!
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Do we have a better vendor that is trusted then?