N=1
ADD
I take small doses of TZ or RT and zero effect on getting me to do things I don’t want to do :).
Would it be different with larger doses, I dunno?
SS-31 did make a difference and I do all sorts of things I would usually put off.
@sunshine4 oddly, LDN did for me what glp1’s do for others… no real love for anything anymore (food/wine)… but, unfortunately, it actually inspires me to eat less healthy because I need more incentive to eat.
I think it is different with higher doses. What type of behavior modification effects are you noticing? Also, just for curiosity sake is your ADD already medicated?
I didn’t know I had ADD until I was aprox 40 (almost 20 years ago). My sister in law had a hunch and handed me an adderall. The clouds parted and the angels sang. Everything became crystal clear (focus, no fog) and I could get things done.
I was on it for probably 60-90 days, an incredible 60-90 days. Then, at a cardiologist appointment, he said ‘do you know it’s speed and causes vasoconstriction and will increase your risk for a heart attack?’… I said, nope, no one told me. I never took it again.
Those glorious 60-90 days… that is exactly how I feel now.
I’d procrastinate and could never get myself do anything I didn’t want to (mostly admin things), but I could hyper focus on things that were in my wheelhouse.
I’m getting tons of things done all the time now. Nothing super human, but I’m just ‘normal’. I also notice it a lot here too. The health/science topic has never come easily for me, not that it’s easy now, but I used to torture myself trying read one of these threads in order to get it to register (and often would fail), but now I can focus on things and my mind won’t wander.
Speaking of feeling great, I had a long meeting with my doc today to go over everything I’ve been doing and to discuss my results… everything is so different now that we decided to do a trial of going off my T3 (staying on T4). I was always sluggish and foggy, but now that I’m not, we are seeing if I still need it (can be a net negative for bones and heart rate, so I thought I’d see).
It didn’t seem like this could be real, but it made sense after hearing @John_Hemming say ADD might be a mitochondrial issue… TA DA!
If I’m reading this correctly you’re not longer taking Adderall for your condition but you say you feel as if you are taking it. What is it you’re taking for this effect?
I’m going to be trialling a stimulant medication soon. I’ll have to keep track of blood pressure and other health markers.
Sorry, I rattled on, as I do, and was not clear…
Correct. I only took adderall for a couple of months, almost 20 years ago. I had not taken anything for ADD prior or since then.
I started taking the SS-31 peptide early January. I had no idea it could have this effect, but when I had so many productive/clear days in a row, I tried to figure out what was different… and then google said this was a real possibility.
If you have ADD, it would be interesting for you to try ss-31 to see if lightening strikes twice?
SS-31 is something I have been curious to try. I’m sure I’ll give it a go some time and I’ll report what happens.
I don’t know why but i feel as if almost everyone has a bit of ADD so if SS-31 effects replicate to others (as it has been the case with you) then has got to be a no brainer. Been on the fence for so long but I have finally given in. I’ll be making a purchase in next couple days and hopefully I get same results as you.
Cross check with Aristotle
This looks/sounds like some kind of AI circle-jerk.
Wow, this is like a room filled with mostly AI garbage. Anyway, the Known Short-Term Adverse Effects are common to all GLP1s, so you could apply almost all the longer short term effects to all of them.
Retatrutide monotherapy matches the effectiveness of anti-PD-1 immunotherapy in a preclinical model of pancreatic cancer
"Results: Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 monotherapy, which achieved a 5-fold reduction in tumor volume. With a 4-fold reduction in tumor volume, RETA + anti-PD-1 combination therapy did not demonstrate significant additional benefit beyond either monotherapy. Importantly, body weight remained stable across all groups, while blood glucose levels were significantly lowered by RETA treatment, indicating RETA’s anti-tumor effects occurred independently of weight loss and may involve metabolic modulation.
Conclusions: Findings demonstrate that low-dose RETA exerted anti-tumor effects comparable to anti-PD-1 immunotherapy in a preclinical pancreatic cancer model, independent of weight loss. Ongoing studies in additional models aim to determine mechanisms mediating RETA’s potent anti-tumor function. RETA may have direct anti-tumor and/or anti-tumor immunity actions that contribute to improved tumor outcomes. Further exploration of RETA as a novel therapeutic strategy for obesity-associated cancers are warranted."
I feel similarly. My only concern is if this type of action stops the incentive of these companies inventing such great medicines.
What is the alternative? I don’t think having these medicines at their current price is fair.
More good news
Zydus plans to launch the drug under three brand names - SEMAGLYN, MASHEMA, ALTERME.
Unlike existing treatments that require multiple single-use pens, Zydus’ single adjustable pen will let patients select different doses, lowering costs, it says.
Zydus holds exclusive rights to its reusable pen with prefilled cartridges.
Patent protection for semaglutide expires in India late in March 2026, triggering a rush among Indian drugmakers to prepare lower-cost versions.
Semaglutide is the active ingredient in Danish drugmaker Novo Nordisk’s (NOVOb.CO), opens new tab blockbuster diabetes drug Ozempic and weight-loss drug Wegovy.
In January, Zydus received approval from India’s regulator to make and sell generic versions of the weight-loss drugs.
Larger peer Dr Reddy’s Laboratories (REDY.NS), opens new tab is likely to launch its generic semaglutide injection in the country in March under the brand name Obeda, Reuters reported earlier on Wednesday, citing two people familiar with the matter.
Me too! I loved Adderall. A doc who prescribed it for me retired, and the others in my orbit are less pharmaceutically inclined. Modafinil, by comparison, is worthless. Unfortunately, I haven’t noticed any mood- or focus-enhancing effects from fairly high doses of SS-31.
Can you describe the difference between Adderall and Modafinil?
Modafinil supposedly promotes wakefulness, but unless you suffer from a sleep disorder such as narcolepsy, it probably won’t do much. At best, it’s a mild stimulant. When pulling all-nighters, which I still like to do even in my seventies, I find that it’s no better than caffeine.
Now, when the U.S. bombed Iran last year, the pilots were said to be popping Modafinil on their 36-hour, round-trip flight. I’m sure that this is true, but we don’t what dose they took, and we don’t know what other meds they were ingesting. My guess is that the military has a whole top-secret pharmacy at its disposal.
Adderall is far more powerful than Modafinil. Providing a huge hit of serotonin and dopamine, it intensifies concentration and elevates the mood. It is great for taking on either the most mundane or the most challenging of tasks. It is also an appetite suppressant, which can lead to its abuse. One drawback of Adderall is that, from my perspective, it raises body temperature, which means that it can lead to overheating.
Speaking of the military, amphetamines like Adderall were distributed to soldiers on both sides in WWII, Korea, and VietNam. This helped them to overcome physical exhaustion, battle fatigue, and even fear of dying. They had pills to psych them up and pills to bring them down. Who knows what they have available to them now.
I’ve been kept up over 36 hours straight when I took 250mg of armodafinil. Never took it again after that.
It does have a long half-life, but it works differently for you. I can go to sleep on it after 12 hours or so.
