I don’t know why but i feel as if almost everyone has a bit of ADD so if SS-31 effects replicate to others (as it has been the case with you) then has got to be a no brainer. Been on the fence for so long but I have finally given in. I’ll be making a purchase in next couple days and hopefully I get same results as you.
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Cross check with Aristotle
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This looks/sounds like some kind of AI circle-jerk.
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Wow, this is like a room filled with mostly AI garbage. Anyway, the Known Short-Term Adverse Effects are common to all GLP1s, so you could apply almost all the longer short term effects to all of them.
Retatrutide monotherapy matches the effectiveness of anti-PD-1 immunotherapy in a preclinical model of pancreatic cancer
"Results: Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 monotherapy, which achieved a 5-fold reduction in tumor volume. With a 4-fold reduction in tumor volume, RETA + anti-PD-1 combination therapy did not demonstrate significant additional benefit beyond either monotherapy. Importantly, body weight remained stable across all groups, while blood glucose levels were significantly lowered by RETA treatment, indicating RETA’s anti-tumor effects occurred independently of weight loss and may involve metabolic modulation.
Conclusions: Findings demonstrate that low-dose RETA exerted anti-tumor effects comparable to anti-PD-1 immunotherapy in a preclinical pancreatic cancer model, independent of weight loss. Ongoing studies in additional models aim to determine mechanisms mediating RETA’s potent anti-tumor function. RETA may have direct anti-tumor and/or anti-tumor immunity actions that contribute to improved tumor outcomes. Further exploration of RETA as a novel therapeutic strategy for obesity-associated cancers are warranted."
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I feel similarly. My only concern is if this type of action stops the incentive of these companies inventing such great medicines.
What is the alternative? I don’t think having these medicines at their current price is fair.
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More good news
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Zydus plans to launch the drug under three brand names - SEMAGLYN, MASHEMA, ALTERME.
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Unlike existing treatments that require multiple single-use pens, Zydus’ single adjustable pen will let patients select different doses, lowering costs, it says.
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Zydus holds exclusive rights to its reusable pen with prefilled cartridges.
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Patent protection for semaglutide expires in India late in March 2026, triggering a rush among Indian drugmakers to prepare lower-cost versions.
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Semaglutide is the active ingredient in Danish drugmaker Novo Nordisk’s (NOVOb.CO), opens new tab blockbuster diabetes drug Ozempic and weight-loss drug Wegovy.
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In January, Zydus received approval from India’s regulator to make and sell generic versions of the weight-loss drugs.
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Larger peer Dr Reddy’s Laboratories (REDY.NS), opens new tab is likely to launch its generic semaglutide injection in the country in March under the brand name Obeda, Reuters reported earlier on Wednesday, citing two people familiar with the matter.
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Me too! I loved Adderall. A doc who prescribed it for me retired, and the others in my orbit are less pharmaceutically inclined. Modafinil, by comparison, is worthless. Unfortunately, I haven’t noticed any mood- or focus-enhancing effects from fairly high doses of SS-31.
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Can you describe the difference between Adderall and Modafinil?
Modafinil supposedly promotes wakefulness, but unless you suffer from a sleep disorder such as narcolepsy, it probably won’t do much. At best, it’s a mild stimulant. When pulling all-nighters, which I still like to do even in my seventies, I find that it’s no better than caffeine.
Now, when the U.S. bombed Iran last year, the pilots were said to be popping Modafinil on their 36-hour, round-trip flight. I’m sure that this is true, but we don’t what dose they took, and we don’t know what other meds they were ingesting. My guess is that the military has a whole top-secret pharmacy at its disposal.
Adderall is far more powerful than Modafinil. Providing a huge hit of serotonin and dopamine, it intensifies concentration and elevates the mood. It is great for taking on either the most mundane or the most challenging of tasks. It is also an appetite suppressant, which can lead to its abuse. One drawback of Adderall is that, from my perspective, it raises body temperature, which means that it can lead to overheating.
Speaking of the military, amphetamines like Adderall were distributed to soldiers on both sides in WWII, Korea, and VietNam. This helped them to overcome physical exhaustion, battle fatigue, and even fear of dying. They had pills to psych them up and pills to bring them down. Who knows what they have available to them now.
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I’ve been kept up over 36 hours straight when I took 250mg of armodafinil. Never took it again after that.
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It does have a long half-life, but it works differently for you. I can go to sleep on it after 12 hours or so.
I think I am going to switch from Reta to tirzepatide. I’m kind of tired of this massive bump in resting heart rate and I’m hearing that it is far less pronounced with Tirzepatide. I’ll probably just do 2.5mg of Tirz and leave it there since i’m not really trying to lose weight and I don’t want too much appetite suppression. 2-3mg Reta spikes it 20bpm
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Some of us are welcoming the increase in metabolism and compensate for it with statins and SGLT2i.
I beg to differ
I’m sorry to hear this @Tim ! I was hoping it would help others more than just me.
I don’t know what I’m talking about, but because you aren’t seeing the same thing, I wonder if it is more about if someone has more damaged mitochondria to fix than their ADD? Or, it just works on people differently, similar to many other things? Just spitballing here.
Also, I posted about this somewhere else the other day, so I’ll have to try to find it to make an edit, but I thought I’d share my one day of having super duper energy after a double dose appears to have been a fluke, sigh. I skipped a dose and then did it again and nothing magical happened.
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For me even low dose mondafinil is like crack - manic energy, euphoria, racing heart, no sleep the whole night no matter when I take it, etc.
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For me, tirz was better for appetite suppression at low doses and also didn’t increase my HR as much as reta, BUT it came with significant fatigue/lethargy as a side effect. If you can get the appetite suppression without the fatigue, then I’d go with tirz for sure.
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