I doubt it will stop working with regard to glucose control when used as prescribed.
It may stop working for weight loss, some have experienced that but so far it is enabling solid weight maintenance for the folks I know.
The weight reduction aspect is a journey, sometimes a long one for some people and plateaus can occur but the glucose control seems to remain functional.
The weight loss function vs the glucose control function are somewhat separate functions.
3x the dose for 3.1% more weight loss. I’d be curious if there are more side effects at that dose.
I’m curious what name brand they’ll come up with once Retatrutide gets approved in 2026. By the time it gets approved, I will have been taking it for well over a year, since I’ve been on it for 8 weeks now, at a low dose.
The only people taking these oral versions are unfortunate suckers who don’t know any better. I know because I was one, although I used the Henry Meds money back guarantee to get a refund since it was completely useless and had zero effect.
Sema and tirz too big to be absorbed across the oral mucosa and are rapidly and completely broken down in the stomach (unless there’s a special patented absorption enhancer called SNAC technology in the case of Rybelsus, which allows a small fraction to be absorbed directly across the stomach wall). Don’t waste your money on the compounded orals (compounded injectables, on the other hand, have been very effective in my experience).
https://x.com/cremieuxrecueil/status/1897181887527059669
I’m going to finally stop holding off and inject mine tonight, I’ve had too much disruption from late night hunger
Apparently this one (Retatrutide) helps with lean mass retention relative to Semaglutide. Not sure why, but maybe it has to do with the effects on the liver.
and for me, the lean mass retention is really important b/c it’s not going to be easy for me to regain it.
Why not, is it the strength training part, or what, if you mind me asking?
I have chronic fatigue (too tired to do things half the time) and ADHD-PI, it makes consistent strength training extremely difficult
but beyond those excuses! The real reason is b/c I want to spend all my time doing knowledge work and it takes away from it.
nearcyan has moderate AGI timelines and uses them to reduce food costs. I don’t need to reduce weight, I just need to reduce how disruptive hunger is to my entire day (i can be hungry enough to eat/drink 9 lbs of food/drink at once, like yesterday when I went from 102->111 lbs (it will go back to 102 very shortly b/c it was ultra-low-calorie, but it’s very disruptive)
Also I have A LOT of noise in my brain (so much theta/delta to alpha/beta ratio) which is strongly associated with ADHD but it makes it hard to focus when doing repetitive things like this beyond the first time
Good stuff. I’ve almost been on it for 5 months now. 3mg per week.
Mind sharing what the X post was about for those of us without an account?
What do people here think of using Tirzepatide weekly but doing a cycle of low dose reta at 1mg a week in addition?
I’ve done combos of Tz and Rt. First time was when I transitioned from Tz to Rt and did a 50/50 combo for 1 month. I switched full time to Rt in a 2 month transition.
I also know 5 people who take a 60/40 Tz + Rt dose weekly. Works well but those are people who are “stubborn” losers and are on a relatively high dose due to hormonal issues (menopause) or having to lose more than 80lb and slowed down at the 50lb loss mark. They picked back up with that combo but in reality these peptides are often dose dependent.
For many things we do, it’s hard to measure and titrate to an ideal dose, like Rapamycin and others. For GLP1’s it’s a lot easier, the scale is all one needs. That’s the beauty of it for weight loss.
I weigh my self daily at the same time, first thing in the morning. I have been doing this for over 5 years. When we started with this in 2023 the goal was 1lb per week. The first couple months lost a bit more, 2.0lb/wk and then we slowly dropped the dose a bit until the 1lb weekly was happening. That took about 4 months.
Do you measure waist to hip ratio? Back in the beginning of 2024 I had 1.086. 26th May 2025 this year I am down to 0.985.
My target is 0.95 or less.
Tirz has been essential in getting this down. I love that GIP directly targets visceral fat.
I can’t be the only one who thinks this is a HUGE deal. Peptide sciences was thought to be the gold standard peptide source. This is a game changer.
Not really a fan of stacking in general, and of stacking these 2 peptides in particular. You’re basically hammering GLP1 and GIP with those 2 which at best is useless, and at worse dimishes efficacy of either.
You’re on a low dose of tirzepatide , titrate up if you want to lose more. Max dose is 15mg. If you really want to use retatrutide, just switch to it and titrate up. Keep things simple.
If you really want to stack, pick a medication that doesn’t hit the same receptors as your base medication. For example, any amylin agonist and tirzepatide or retatrutide. Or mazdutide and tirzepatide.
Makes sense. Thanks. I’ll just stick with tirz, it’s working very well.
I sent this to a friend of mine. He went and got his Retatrutide from peptide sciences labs tested and it turned out to be underdosed tirzepatide.
He sent it to the company and they gave him a huge credit and did a big apology thing. So hopefully they clean up their act now that they’ve been caught red handed more than once.
That is really scary if, for example, someone was choosing RT because they discovered they were allergic to TZ.
Thanks for the share… and thank your friend for sending it to be tested… he potentially helped a lot of people!
