Good stuff. I’ve almost been on it for 5 months now. 3mg per week.
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Mind sharing what the X post was about for those of us without an account?
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What do people here think of using Tirzepatide weekly but doing a cycle of low dose reta at 1mg a week in addition?
I’ve done combos of Tz and Rt. First time was when I transitioned from Tz to Rt and did a 50/50 combo for 1 month. I switched full time to Rt in a 2 month transition.
I also know 5 people who take a 60/40 Tz + Rt dose weekly. Works well but those are people who are “stubborn” losers and are on a relatively high dose due to hormonal issues (menopause) or having to lose more than 80lb and slowed down at the 50lb loss mark. They picked back up with that combo but in reality these peptides are often dose dependent.
For many things we do, it’s hard to measure and titrate to an ideal dose, like Rapamycin and others. For GLP1’s it’s a lot easier, the scale is all one needs. That’s the beauty of it for weight loss.
I weigh my self daily at the same time, first thing in the morning. I have been doing this for over 5 years. When we started with this in 2023 the goal was 1lb per week. The first couple months lost a bit more, 2.0lb/wk and then we slowly dropped the dose a bit until the 1lb weekly was happening. That took about 4 months.
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Do you measure waist to hip ratio? Back in the beginning of 2024 I had 1.086. 26th May 2025 this year I am down to 0.985.
My target is 0.95 or less.
Tirz has been essential in getting this down. I love that GIP directly targets visceral fat.
I can’t be the only one who thinks this is a HUGE deal. Peptide sciences was thought to be the gold standard peptide source. This is a game changer.
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Not really a fan of stacking in general, and of stacking these 2 peptides in particular. You’re basically hammering GLP1 and GIP with those 2 which at best is useless, and at worse dimishes efficacy of either.
You’re on a low dose of tirzepatide , titrate up if you want to lose more. Max dose is 15mg. If you really want to use retatrutide, just switch to it and titrate up. Keep things simple.
If you really want to stack, pick a medication that doesn’t hit the same receptors as your base medication. For example, any amylin agonist and tirzepatide or retatrutide. Or mazdutide and tirzepatide.
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Makes sense. Thanks. I’ll just stick with tirz, it’s working very well.
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I sent this to a friend of mine. He went and got his Retatrutide from peptide sciences labs tested and it turned out to be underdosed tirzepatide.
He sent it to the company and they gave him a huge credit and did a big apology thing. So hopefully they clean up their act now that they’ve been caught red handed more than once.
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That is really scary if, for example, someone was choosing RT because they discovered they were allergic to TZ.
Thanks for the share… and thank your friend for sending it to be tested… he potentially helped a lot of people!
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If there was any doubt before, virtually of these US peptide sellers don’t actually manufacture anything, they simply buy the finished product from the world’s manufacturing center. Their QC is obviously terrible or non-existent. I think I’ve said that somewhere else, but: do not buy from single vial peptide vendors. Your ability to test and ensure you get the right product is very limited when you do so. The COAs provided by vendors are nice, but cannot be trusted.
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Yea I’m pretty stringent on needing to see 3rd party lab testing before ordering these days.
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To add on to what he said:
“I need to be fair on Peptide Sciences. They have given me a credit for $450. Covers the testing cost and $100. As well, they sent replacements for my Reta bottles out today overnight.”
I still will be ordering elsewhere but it looks like they are at least admitting fault and apologizing.
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While that is very nice, I would only be impressed if they immediately sent out replacement bottles and an informative email to everyone who has ordered it, even those who have no clue they have a fake in their possession.
Now, THAT would be impressive. Taking care of the guy who caught it, while nice for him, does not impress me in the least. 
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I’ve personally tried these GLP based variations attempting to find the sweet spot for myself:
- Triz 4 mg / week divided over two doses of 2 mg. This was great at lowering my fasting glucose (upper 70s to lower 80s), A1C (4.9) and helped me have total control over what I ate but left me a bit fatiqued as the negative.
- Reta 3mg / week divided over two doses of 1.5 mg. Fasting blood glucose and A1C went back to normal (lower 90s and 5.2). So Reta is not great for glucose control in my situation. There was no fatigue. Food choices were totally under my control.
- Reta 1 mg and Triz 2 mg. This combination is giving me great fasting glucose and A1C (upper 70s and 4.9). There is no fatigue. Food choices are totally under my control.
This last combination of (Triz 2mg + Reta 1mg) per week appears like it’s the best of what I’ve tried so far. Just an N=1.
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Are you staggering these doses during the week? I wonder how it would be with 2mg reta and 1mg tirz?
Also, did you lose weight/fat on the above combinations, and if so which seems most effective for you? Thanks
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Hi Davin8r,
For dosing, the current protocol is 2 mg Triz on Tuesday and then 1 mg Reta on Friday.
I’m pretty lean already at 12% body fat per my last Dexa in Jan after 3 months of Triz at 4 mg. I’m guessing I’m a bit lower in BF now. I’m not trying to loose weight but to put on muscle and maintain the low BF. Traditionally my body wants to naturally be at around 15-18% body fat. Since starting the GLP1 protocols the set point on body fat is 10-12% at current dosing. With weight training and eating as much as I can of a healthy diet (high protein, vegetables, high fiber, healthy fats, low to medium carbs) I’m trying to gain muscle while staying low fat.
With all 3 of those protocols I have to eat more than normal to prevent from loosing weight. It would be easy on all 3 protocols to eat way less and if I wanted to loose weight. I think all 3 are equal in terms of weight loss for me personally; perhaps reta is the best. My goals with GLP1 are more glucose control, potential other longevity benifits (kidney, heart, Alzheimers, osteoarthritis), body composition improvement and to have an easy time to eat very healthy. The GLP1’s for me make eating food more functional than pleasure based. Lean boneless/skinless chicken and vegetables vs juicy burger/fries are both equal to me under the GLP1 so I always go with the chicken and veg.
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Not just third party lab tested, because these guys don’t trace their peptides at a lot level. I need lot level info and tested by end customers by a reputable lab (Janoshik), that is why I prefer buyers groups.
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Cremieux is DA retatrutide guy…