Researchers reveal new molecular mechanism for stimulating hair growth

@Agetron Thanks. Do you use any sort of micro needling to help minoxidil do its thing? I wonder why finasteride and minoxidil worked on certain parts of your scalp but not others.

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You use 5mg of minoxidil nightly? That is impressive I can only manage 1.5mg before my scalp in too wet and it starts getting all over the place.

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I believe he means oral minoxidil.

@Joseph_Lavelle Hair follicles that have been damaged for years or decades will take longer to recover and might even need stronger DHT inhibition than what finasteride by itself can achieve.

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Yes, I take minoxidil orally and finasteride.

Finasteride is great for keeping your prostate small and reducing cholesterol in your blood… less opportunities for calcium and plaque build up. And, of course, hair retention.

I have not tried microneedling, but if I start to see some success with this new tonic of 2-Deoxy-D-ribose (2dDR); then, I might consider it.

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I get mine this Wednesday looking forward to trying it out.

I did read that this 2dDR works because it causes oxidative stress. However too much could damage the hair follicle so combining it with other things that reduce the inflammation response or other stresses might be a good idea??? (Diet supplements exercise you know the drill)

I guess, rapamicin, reduces inflammation so it could be a good combo???

The topical 2dDR I am getting includes these two things:

Copper peptides
Cinnamic acid

Which I hope is also a good compliment.

Living breathing bumbling human experiment untill it’s all over. :sweat_smile:

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It has been over 2 months now. Anyone been using 2dDR and can report visible results? Especially those who had already stabilized their hair with existing medication already.

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Mine is in the refrigerator. Been busy with summer activities and travel. Just got back and will start my test in the next week or so.

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I’ve been using Elevai facial serum for about a year and like it. I can not speak to if the exosomes/stem cells work, but my skin has been happy. I might be a sucker parting with their money (but I’m using a 20% off holiday code, so there’s that!)

I see they are introducing a scalp product. (I’d skip their shampoo/condiioner)

Does anyone believe this might potentially work?

Here is a screen shot… the visual is so dramatic that I tend not to believe it. It’s being introduced in January, so there is not too much info out there on it yet.

I currently use rogaine aprox 3-4x a week as a hopeful preventative.

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Hey @Agetron @RapAdmin - how are you two making out with the 2-Deoxy-D-ribose? I just tried to order some today.

As an update: I have been playing with ‘the formula’, adding and subtracting things over time. I also started oral minox a couple of months ago. I started at 2.5mg, no issues. I increased the dose to 2.5mg plus 1/2 a 2.5mg pill of 3.75mg. I noticed some swelling in my legs this week and my ankles ballooned up. I reduced back to 2.5mg.

I also ordered the ‘roots’ kit to see what my DNA said. Interesting readout.
Provider_TRI65317AA_202412111116.pdf (378.3 KB)

Too early to tell how their formula compares to mine. I will prob try it for a couple of months and then DIY it. It isn’t too expensive.

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If you’re using oral minoxidil it makes no sense to continue 2DDR because it’s impossible to tell whether you got any additional growth on top of oral minoxidil.

Looking good Dan.

Actually,I have really cut back on hair treatment application to every 3rd or 4th day – (to my detriment).
Hair is currently at its thinnest. I didn’t see the big change with 2-Deoxy-D-ribose - but, I’ve been thinking.

I am going to go at harder… every other day… create a solution of 2-Deoxy-D-ribose to go on hair in shower like a conditoner, but I don’t wash out I towel buff in. Going to try it.

Will see how that does in the next 3 months.

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Yeah I understand stacking makes it hard to sus out what is working. I just keep rotating through things hoping I will be one of those people with before and after photos where people are like, “wow, I want to try what that dude is doing”. :slight_smile:

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There is pre-mixed ribose gel on Etsy.

I got the below gel (.5%), two weeks ago.

https://www.etsy.com/listing/1810743732/2-deoxy-d-ribose-05-gel-3-month-supply?click_key=b2aab93499efaf1ffea334402c5f27d21942fcf5%3A1810743732&click_sum=f148b3e0&external=1&rec_type=cs&ref=pla_similar_listing_top-4&frs=1

Turns out there is a more potent version (2.5%)

https://www.etsy.com/listing/1855496651/2-deoxy-d-ribose-gel-high-potency-25?gpla=1&gao=1&&utm_source=google&utm_medium=cpc&utm_campaign=shopping_us_all&utm_custom1=_k_EAIaIQobChMI15_ag5iCiwMVnjUIBR1bLiSAEAYYAiABEgIdlPD_BwE_k_&utm_content=go_21500569332_164907277083_707558291651_pla-293946777986_c__1855496651_12768591&utm_custom2=21500569332&gad_source=1&gclid=EAIaIQobChMI15_ag5iCiwMVnjUIBR1bLiSAEAYYAiABEgIdlPD_BwE

Will try that later. I have been on topical zizyphus jujube oil for about five days now.

https://www.ergo-log.com/chinesedateoil.html

*The oil from seeds of the Chinese date – full name Zizyphus jujuba – enhances hair growth. Rub the oil into the skin on your head, and your hair will get thicker. At least that’s what happened with the mice that researchers at Daegu University, Korea, did experiments on. The researchers published the results of their study in Food and Chemical Toxicology.

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Ah - I’ve been too busy to focus on this. I still have it sitting in my refrigerator waiting for testing. Sorry - no results to report as yet.

I was taking minoxidil 5mg per day for about 6 month and while it seemed to halt any loss, it didn’t lead to any new growth. Now I’m trying a Finasteride 0.3% Minoxidil 6% Serum by HIMs. No results to report yet.

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So I made my skunk works conditioner for after a shampoo. The problem was just putting it in dry hair made it sticky and wouldn’t dry.
Now trying 2-Deoxy-D-ribose again in the shower. will be more consisitent if it goes on and dries better.

Receipe:
2 tablespoon of 2-Deoxy-D-ribose (2dDR).

1 tablespoon of Sodium Alginate

1/2 fluid ounce of Propylene glycol (PG)

1/2 fluid ounce of Phenoxyethanol

1 fuild ounce of 5% minoxidil topical solution

5 eyedropper squirts of 99.9% DMSO unscented

All mixed together. Will use in a few minutes.

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I would think the sodium alginate would thicken the mixture excessively (?).

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It went on fairly - liquidly… I let it set for 10 minutes while I lotioned up… . put on cologne… got dressed.

Buffed it with a towel… then buff it again at a half hour. It looked fine…now if it will grow the fine hairs… lol.

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Gotcha, thank you @RapAdmin - out of curiosity did you ever get any edema from the oral Minox?

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