“However, the GAL-INT Study Group5 reported that recorded mortality due to cardiovascular event was greater in the galantamine group than in the placebo group, and interestingly, about half of the deaths in galantamine appeared to result from various vascular causes (myocardial infarction, stroke, and sudden death).”
I haven’t looked at the GAL-INT study, but this did catch my eye…
Hard to find the exact study - here are some of the Gal-Int studies:
https://www.neurology.org/doi/10.1212/01.wnl.0000303815.69777.26
That study they cite has a much higher dosage for what it’s worth:
The purpose of this study was to evaluate the efficacy and safety profiles of galantamine 24 mg/d in patients with VaD or AD with CVD over the longer term (>6 months).
I found this:
with 8mg galantamine hydrobromide, which this trademark info page
says is equivalent to 8mg galantamine base.
The FDA pdf is an excellent read.
“Through their primary action, cholinomimetics may be expected to increase gastric acid secretion due to increased cholinergic activity”
Unfortunately, I am experiencing this at 8mg/day without food. After reading the paper I will try to take it only with food.
Even sourcing it from India it is quite pricey. I recently bought 300, 4mg tablets from India at ~ 50 cents/4 mg, including shipping.
I am using it more as a nootropic sleep-enhancing drug. This may not be suitable for everyone as the effect on dreams varies widely according to Reddit users, etc.
Hi
Reading up on this thread with interest but confused on one point and practical issue on another.
Metformin 500mg
Leucine 1.2g
sildenafil 4mg
Firstly can you confirm this combination requires galantamine in addition to the above? The thread started with the synergy of Metformin and Galantamine ( which of itself was interesting) then appeared to go AWOL and move on to just the three mentioned above without including Galantamine
My take and what I will now move on to is:
Twice a day:
Metformin 500mg
Galantamine 4mg
Leucine 1.2g
sildenafil 4mg
Secondly, is Sildenafil available in 4mg? I can find nothing outside of 50/100 etc etc - wondered how people were dosing at these low levels from commercially available supplies?
Be grateful for any comments
Best wishes
Steve
Unless you have unwanted side effects, why not take the full dose of sildenafil?
I switched to tadalafil because I want to have a more continuous level in my blood
and it’s more convenient to take once a day. Many in the longevity field who are smarter than me take tadalafil over sildenafil for this reason.
What about this from Alldaychemist?
I have started 4mg Galantamine (from India) added to my morning stack which contains 500mg Metformin.
I have multiple sclerosis (in long term remission) and have been doing rehabilitative physiotherapy for muscle atrophy after a previous demyelinating relapse (that remyelinated but the muscle atrophied in the interim).
My strength has gone ballistic. My balance and gait is phenomenally improved. This drug is going to be a game changer for muscle atrophy and age attributed sarcopenia. Also @John_Hemming you might want to explore the amazing mitogenic and ROS protection through hydrogen peroxide effects of Galantamine.
Great to hear. I’m going to try it on my father now, given your good results!
I’m supplementing with additional choline with 4000 mg Arctic krill (phospholipids) and a triple form of choline (for the acetylcholine too). Amazon U.K. link
Vegavero Choline Complex | 3 Forms: Bitartrate, CDP & Phosphatidyl | NO Additives, Lab-Tested | 90 Capsules | Vegan https://amzn.eu/d/06fw3y00
P.S. I also add 20mg of Calais due to the 70% reduction in vascular dementia risk.
Then, also, other synergies as part of my experimental stack is 15 grams of Chlorella (split into two 7.5 grams AM PM, from tablets as I can’t abide the taste) with
LABO Nutrition NeuroREGAIN - Scallop-derived PLASMALOGEN for Memory, Alertness, Learning, Concentration and Other Cognitive Functions – Suitable for Seniors, Adult Men & Women https://amzn.eu/d/09DvVPRX
Because, plasmalogens with Chlorella do this:
@Walter_Brown Do you think the great results are the Galantamine or the Galantamine in addition to other substances? Thanks!
Not sure,I think it is the correct pathway they’re targeting with Galantamine
Anyone have a good source to buy Galantamine? Jagdish doesn’t sell it. Thanks!
Have noted a reduction in HRV, which seems odd. Have upped my resonant breathing and considering the neurosym.