These are the enteric-coated capsules that I have been using for the last several years. I don’t know which brand is superior. I put up to three tablets in a capsule.
I need to redo a little experiment that I did a few years ago but with rapamycin tablets in enteric-coated capsules.
I repost a little experiment that I did in 2023, Zydus vs. Biocon, to see approximately how fast they dissolve in stomach acid. Using distilled water and hydrochloric acid, I made a solution with a pH of approximately 1.5, heated the solution to 98 degrees F, and dropped the tablets in.
They are completely dissolved in a little more than 10 minutes, except for the excipients.
As an MD and big rapamycin prescriber and PI on several studies, I gotta ask: what exactly is the target? As a longevity drug and/or ME/CFS/LC drug I don’t thing we know the target plasma level either peak or trough. We generally look for very low to zero trough but what is the ‘best’ peak. We are working on that data from our two studies and hopefully will be able to correlate levels with outcomes on the validated questionnaires. The Pearl study looks at levels but not related to outcomes.
My thoughts on this are that we wish to see the most intense selective mitophagy at any one stage as that should knock out a higher percentage of damaged mtDNA. OTOH there are side effect from high doses. Hence the balance point is unclear.
You are raising the larger issue, and I agree completely. For longevity specifically, we have no human study that measures a longevity endpoint at all – so there’s nothing to anchor a target level to. What evidence we have rests on upstream markers whose connection to human lifespan varies in strength and remains open to interpretation.
Without outcome data there are no validated serum targets – not peak, not trough, not AUC, not time above threshold. The near-zero trough most of us aim for is borrowed reasoning: keep mTORC1 inhibition intermittent and avoid the sustained exposure tied to immunosuppression and mTORC2 effects. Sensible mechanistically, but derived from no longevity outcome – and the “best” peak is entirely undefined.
Your own studies may be among the first to tie measured levels to validated outcomes – in ME/CFS and Long COVID rather than longevity per se, but exactly the level-to-outcome data the field otherwise lacks.
A fuller treatment of N=1 use here would have to weigh two gaps. First, risk versus reward – where we have reasonable indications on both sides but no endpoint-based guidance to calibrate them. Second, the likelihood that benefit is person-specific – plausible, but barely actionable: we have few inputs to individualize dosing against, and fewer still validated outcomes to measure benefit by. Even a genuine responder would be hard to distinguish from a non-responder, because the readouts we’d judge by are surrogates of uncertain relevance. That second gap is the one your studies are starting to close. Until then, those of us taking rapamycin as a geroprotector are running N=1 experiments ahead of the science.
If we are after intense mitophagy, should the Rapamycin dose be combined with a couple of days of fasting? Or perhaps several days of caloric restriction? The downside is loss of muscle and bone, so this could not be done more than once a month
I have been taking Siroboom 6 mg/week for a couple of years.No side effects and not sure if there is any effect. Concerned about the negative comments about this brand in this forum. Considering getting drug levels to determine if it is actually absorbed. Looks like the various brands and manufacturers are all over the map. Even some of the original US brands are now being produced offshore.
Indiamart is interesting. You have to log in to search for anything and then your email and text blow up with messages from sellers. Very annoying.
Would be nice to have the sirolimus brand names associated with the various reputable companies mentioned here.
You wrote: “Considering getting drug levels to determine if it is actually absorbed.”
Yeah, sorry… that should have been done at the start buddy. Siroboom has been panned for years on this site as barely to no absorption.
Quality and Potency Feedback
Inconsistent Lab Results: Independent user blood tests and lab assays show wide batch variances. Some users found tablets under-dosed (yielding very low blood concentration levels relative to the amount taken), while others found individual batches over-potent or accurately dosed.
Community Caution: Experienced online health communities generally advise caution or avoiding Siroboon due to these unpredictable batch profiles, preferring larger, more established generic manufacturers.
Likely it’s been a waste of your money… and longevity goals.
Rapamune, siriolimus, zydus… have been the gold standard for rapamycin prescriptions.
Even with my USA pharmaceutical grade rapamycin prescription… I have done all 3 by-the-way (rapamune, siriolimus, zydus)… and checked my absorption every 4-6 months with a Labcorp blood draw… for the past 5 years. Next, test will be in a month.
Every 1 mg rapamycin or generic version -rapamune, siriolimus, zydus… should produce 3 Ng/mL of affect in your blood . For example 6 mg should produce 18 Ng/mL in a Labcorp test for siriolimus.
This came form a Matt Kaeberline podcast 1 mg = 3 Ng/mL. taking a blood draw at 2 hours post dose. I take 6 mg sirolimus weekly. My Labcorp results is typically 17.8 Ng/mL
Well, to each their own. I don’t find Indiamart “interesting”, I find it a pest. I avoid it altogether. I only deal with sellers directly, not through Indiamart. Go through the dedicated threads on purchasing rapamycin, and you’ll find recommendations for sellers and feedback over time. Sift through those recommendations, follow over time to see if the feedback is consistent, and hit up a seller or two. If you are satisfied, you stick around, otherwise you pick the next one. That’s what I did. I went through a few sellers before I found ones I was satisfied with (always provisionally - things change). I looked into Indiamart and bailed ASAP when I realized what that trap was all about - it’s like those bazaars where they trap unsuspecting tourists and ply 'em with products until you’re left penniless carrying a bag of rubbish and everyone shouting to buy more from them. No thanks.
And the protocol is simple. Any drug you want, first establish which brand is the best, what the dosages are available and price. Do research first. That way you don’t end up with dodgy stuff like Siroboom. I cannot imagine just ordering a random brand of powerful medication with doing zero research. The info is available. Always, always, always do thorough research first: do I really want this med and do I know all I need to about it, what is the best brand, who is a good seller/source, how much does it cost. Only with all that info in hand do you spring into action. It’s the old carpenter rule: measure twice, cut once. Research first - no exceptions.
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