That’s right based on my N=1 testing.
When I first started rapamycin 4 plus years ago… I thought GFJ would double or triple the dose effect. Not so… 30% increase.
You get the equivalent of 1 mg extra from a 6 mg dose.
It is better than nothing if you are saving your pills.
That’s how you know if you have quality rapamycin. At 2 to 3 hours, Labcorp test gives you 3ng/mL per 1 mg.
I tested a Chinese guy’s stuff not long ago because he couldn’t get the test. Was good stuff.
GFJ multiplies around on 2,2 for me (with about your dosage. 2 times, 2-3 hours before and together with R). so, 2mg + GFJ is like 4,4mg. But (maybe) its strangely prolongs the trough. extremely. Like 7-8folds)
The amount, type, your physiology, and timing all affect the response. I can tell you this, canned GFJ doesn’t work very well, or perhaps not at all.
FWIW: from various AIs, but references are provided.
“The “Multiplier” Effect: Studies show that grapefruit juice typically increases rapamycin’s AUC (total drug exposure over time) by about 3 to 4 times (300-350%). This is distinct from Cmax (peak concentration), which may increase by a different factor.”
“This means the exact “multiplier” effect of grapefruit juice can range widely, from 0x to over 8x, even under the same study conditions.”
Types and packaging:
Lower Furanocoumarins, But Still Potent: Among colored varieties, Ruby Red has been shown to contain significantly fewer furanocoumarins—up to 60-70% less—compared to other varieties like Marsh White or Flame. However, as with all commercial juices, a standard serving of Ruby Red juice is still likely to cause a significant interaction.
“Reduced Interaction Potential: Juices that are “hot-filled” (pasteurized at high temperatures) or stored at room temperature for long periods (shelf-stable) show a decrease in potent furanocoumarins like DHB”
I’m a patient of Dr. Fraser’s, and I highly encourage everyone to test. That is the key.
While there are guidelines, they are general at best with wide personal variation. You only know your personal response (which is the only response that matters) from testing.
For example, we did two separate tests for me, with and without grapefruit (normally eat half a grapefruit daily with breakfast while in season), and we were both surprised that my results barely elevated at all with the grapefruit. The difference at 50 hours was so small that it was inconsequential, which is apparently quite rare.
Information worth knowing…
