At the risk of beating a dead horse, discussion in another thread made me realize how little I know about the correct dose. So, two specific questions:
What parameters do you use to determine you are taking enough Rapa?
What parameters do you use to determine you are taking too much?
I have decided that I don’t think I’ll truly “know” if I’m taking enough rapamycin ever (or at least for the next decade or more…
Given that - that “higher generally tends to result in bettter longevity results” in all the animal studies (except one, where they maxed out in female mice and the longevity gains plateaued at 128ppm, if I recall correctly)…
My belief is that the best we can do is test different dosing levels and timing approaches on our own bodies, track blood test and functional results closely - and modulate in a way that we think will optimize results.
I think daily dosing in mice is roughly equivalent to about once every 4 days or so in human terms given the speed that mice metabolize rapamycin is about 4 times faster.
My approach has been increasingly to optimize around avoiding the “too much” issue, and doing this by tracking and mitigating all the possible negative side effects, which for me seem to be around lipid increases. I’m in the phase of testing and monitoring different rapamycin doses, and lipid management approaches, from diet to medications and supplements - testing them all. I’m early in this process, so nothing to report yet.
The problem with increasing dose, if my math is right, is that if you double your dose, you add a full half life to clearance time which is another 62 hrs.
Of course we don’t even know how much clearance is needed.
Check with hospital labs (especially transplant clinics) they do this test routinely. I was also thinking it is not available but phoned the transplant clinic and they have it and it is quite inexpensive out of pocket too.