Rapamycin and Visceral Fat Reduction

The luxury of eating every day, how impressive.

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Someone here needs try this out:

Polar reveals new visceral fat measuring technology for wearable devices

Polar is working on a new visceral fat measurement tool. Visceral fat is stored around internal organs like the stomach and liver and has been linked to health conditions such as diabetes and heart disease. However, it has historically been harder to measure, with previous methods including a CT scan or MRI.

Rumors about this new Polar technology started when a patent filing for a dual-purpose wearable strap was uncovered earlier this month. The document describes a device that could be worn around the chest or abdomen, with the ability to measure heart rate and compute “a quantity of fat tissue in the abdominal area on the basis of the received body composition measurement data”.

In a recent interview with Wareable, the company has officially confirmed that it is developing this technology. Polar representative Jari Miettinen said the company wanted to “bring a more sophisticated level of health monitoring to wearable devices”. However, they would not confirm whether or when the visceral fat measuring feature could reach a consumer wearable, stating that “this remains an active area of research, with decisions on potential commercialization to be made based on further results and strategic evaluations.”

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I wonder if this might be the mechanism of visceral fat reduction with rapamycin:

Autophagy is a highly conserved cellular recycling process essential for homeostasis in all eukaryotic cells. Lipid accumulation and its regulation by autophagy are key areas of research for understanding metabolic disorders in human and model mammals.

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Reasonable argument… I lost at least 20 pounds of visceral fat after 3 months of rapa dosing… it just melted away – a pound every few days.

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Well, I did not lose 20 pounds of visceral fat in 3 months (your steak eating self has definitely won the genetic lottery!!!), but I just did my DEXA, and from my last DEXA 3 years ago, I went from 1.37 lbs to .84 lbs visceral fat.

I lost 4 pounds in that timeframe, so I guess some of that is natural. But, I gained 1.5 pounds of muscle (I barely have any in the first place, so the bar was low).

I’m doing more resistance training and started rapa. I’m only sharing incase some of it was from the rapa, but I have no way to know!

My numbers are meager and I don’t expect a parade, but my aging self will take what I can get!!!

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Whoo…hoo!
Congrats. Any numbers in the right direction as we age is fantastic news.

I started losing a pound at 3 months… rapa use,. but definitely had lost 20 pounds within a few months (it was mostly visceral according to my physician)… as my body size and look stayed the same…I lost the hidden fat. Once it started falling away… kept losing until it was gone.

I think guys can knock fat off a lot faster in general. We can get to a smaller BMI… not even achievable by women… based on charts… and body images.

Your muscle :muscle: growth is pretty fantastic… the older the harder it is to gain.

Looks like rapamycin is a great choice… eliminating what is not needed…growing what is needed…continue measuring and keep us posted.

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What an enthusiastic and motivating response! Thank you!!!

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Physionic just released this video on visceral fat reduction.

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I’m really hoping for some serious midsection fat reduction starting like NOW. As a formerly thin woman, now on hrt in midlife, I truly did not expect this challenge. I’ve been on rapa for about 9 weeks.

Are there any rapa users who can share their inspirational stories of regaining a waist if they let theirs go?

Or if you have any other tips and tricks, I am all ears.

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Allow me to introduce you to @Agetron
He is all the inspiration you need.

My only personal tip and trick is to be WFPB because you can eat a significant volume of food without ever thinking about it. It’s not that you can’t gain weight, but it is a lot harder to do.

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Oh my, my mind translated WFPB to mean, “Well Fed Prior to Bed”, and knew that wasn’t quite right. Lol, wishful thinking! I just looked it up and Whole Foods, Plant Based, makes more sense!!!

I actually was a prolific morning green tea/matcha drinker for 15 years, and stopped 6 months ago. It’s exciting to think that returning to this habit may help. Also, your words have inspired me to actually log my food intake since I might be surprised at what I am actually eating.

Yes, his story is inspirational, and I will gladly take all inspiration. However, I have to give extra points for stories from post-menopausal women because I am now a believer that this state is a unique one.

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Hahaha thanks Beth!

For me it was at the 3 month mark (week 14-ish) that the visceral… tummy fat slowly started to melt off… a pound … then another one in a few days… finally about 15 pounds in a month 20 pounds by month two.

Actually the amount of weight loss was initially scary on this new medication. But, muscle and tone remained. Once the visceral fat was purged… tummy fat… I stopped losing weight.

Rapamycin protects needed areas… rids you of just the excess. Using a DEXA scan… all visceral fat gone.

For 3 months… nothing seemed out of the ordinary except arthritis pain stopped… and dysphagia (choking) stopped all at that 3 month mark. No clue or symptoms that this weight drop was about to start. It just clicked on.

Now I am hungry constantly… and eat non-stop. No weight gains. Weird.

Hang in there.

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Four months on rapamycin reduced my visceral fat. It has not come back in the two years I have been off it.

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Well fed prior to bed!!! Love that so much!

If you are going to try logging your food, I’ll suggest you check out Cronometer.com. Use the free version. It’s a great tool many nutritionists use. I use it every blue moon to check out my macros and protein intake to make sure I’m on track.

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Just IMO, if your main target is visceral fat reduction, I’d go with a GLP med (semaglutide or tirzepatide, for instance) over rapamycin. There’s much more human data with fat loss from GLP meds. Also, with GLP meds you get reduced LDL cholesterol and increased insulin sensitivity, whereas rapamycin can elevate LDL and reduce insulin sensitivity. We also have data showing GLP meds decrease risk of heart attack, stroke, fatty liver disease, possibly dementia and more, whereas the data for rapamycin is much more speculative and uncertain, with nearly all studies being done either in animals or with daily use in organ transplant patients as opposed to one dose every 7-14 days.

I’m not saying rapamycin is inferior across the board, just that when it comes to fat reduction, we have a LOT more hard data with GLP meds.

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I’m post menopausal and also feel it’s a bit of a special situation. We generally need a little less energy but still need adequate nutrients.
I took 3 nutrition courses in 2023 after starting rapa because I felt I owed it to myself to improve my eating habits if I wanted to be in this for the long haul so to speak. My goal wasn’t to lose weight necessarily (although it is for most people) but to transition off an animal foods based keto diet which was causing visceral fat gain. I learned how different Macro-nutrients were impacting my blood glucose which was quite enlightening. I also drastically improved my micronutrient intake. I think both of those go a long way toward feeling my best, having the energy to workout and just generally enjoy life more. I was already on rapa for 6 months so it hard to separate out which had the biggest impact but regardless I’m glad to have both in my life. I’m still using the things I learned about myself during the courses and think for me personally finding a way of eating that works for my body is really important at this stage. My body no longer seems to be as forgiving of a poor diet. I’m definitely pleased to be at my high school graduation weight at age 55. I realized when it was all said and done I basically eat according to the American Heart Association guidelines hahaha!
I second the cronometer recommendation. If you’re interested in the micronutrient content of foods be sure to use the NCCDB or USDA entries to get the most accurate data.
The combination of rapa and eating well has been a winner for me.

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This is probably true, but I get the feeling that right now in the USA, given the overwhelming popularity of GLP1s, they are perhaps a lot harder to get. Perhaps my impression is mistaken.

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annodately I have 3 people in my cycle who all had reduced visceral fat. Only one is on GLP1s.

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Yes, I don’t think I would meet any criteria for a glp1 med. I am all in on green tea and rapa, and will post my subjective results as I progress.

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Very true that access to branded GLPs is limited, but as of now, you can still get them via online telehealth providers and compounding pharmacies. For those who just need to trim some fat rather than lose 100+ pounds, a small dose goes a long way.

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