Rapamycin and toenail fungus onychomycosis

I finally gave in to my fears of terbinafine tablets a few months ago and went to my dermatologist for a prescription. She noted that liver problems were quite rare and that blood tests would be done to check for any problems. None were found. I followed the protocol of one 250 mg tablet daily for three months in a row and the fungus appears to now be gone. I wish I had done it years ago instead of suffering with the problem for so long and experimenting with so many useless home remedies.

I am with you Jay… 2-years with this was way too long. I found the terbinafine worked 100% and had no liver issues based on blood tests taken by my physician one month after starting terbinafine to be sure all was good. It was normal.

For me it is the answer to toenail fungus and I think adding DMSO with rapamycin as a topical treatment simulataneously didn’t hurt… and likely helped a good bit.

I plan to continue to take a 500 mg tablet once a week for a while, and then maybe once a month. Do not want this ever again. Also, I will continue to do daily DMSO/rapamycin topical for a few weeks then maybe drop that to once a week too.

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I made a concoction of dmso with cinnamon essential oil for a friend. It took about 1 1/2 years to clear, but it worked. I like the idea of using rapamycin. I just need another friend with toenail fungus!

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Hey Agetron I got the same exact DMSO you use. Now maybe a problem. My latest rapamycin shipment from India left Mumbai 11 days ago and I haven’t heard anything since so I’m concerned. Hopefully it shows up soon.

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Here’s hoping all is just slow in the mail.

Just crush 3 rapa tablets… add some DMSO a few droppers full and a squirt of water - make it stay liquid for applying. Apply with a Q-tip.

I am making more tonight.

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The Dirty Drug in the Ice Cream Tub - It is a great story! I’ve listened to it a few times, and shared it with family and friends. It gets people interested in Rapamycin so much more than just presenting the “facts” around rapamycin. People love a good story - and this has a great story.

I contacted the podcaster (a doctor) - and suggested he do a followup podcast with more of a focus on the past decade of rapamycin in longevity. He said he’d think about it.

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Soak your feet in hydrogen peroxide (about $5) at supermarket… and keep your feet uncovered for a week or so

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Time for a photo update. Dosing Terbinafine HCI oral 250 mg once a day… and 6 squirts of pure DMSO with 6mg crushed rapamycin brushed on toes each morning - fungus gone (lived with it for 2 years). Started April 20th and today… about 5 months. Gone!

This afternoon. September 10, 2023

5 months ago in April 20, 2023.

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Thought we were due for an update… I am now off my terbinafine pills (was taking every few days) and off my DMSO with ground up rapamycin as a topical treatment.

Success!


This morning. November 29, 2023

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Maybe I could be your 'friend’:wink::wink: with a problem toe nail.
Sincerely,
Jan

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Yeah sure! My “friend” used clove oil in dmso about 1::10. A few drops daily with occasional thinning the nail with a device (not sure what it’s called) that is basically a spinning emery board. Took about 5-6 months though. If it comes back I would definitely donate a rapamycin for the mixture. Good luck.

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Happy 2024💥
Thanks Coach❣️for your advice.
I’m on it, as soon as I receive my Clove oil delivery.
Sincerely,
Jan

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If you are going this direction… no terbinafine.

Then, I suggest you add a few crushed pills of rapamycin/siriolimus/rapamune /zydus… whatever brand of rapa you have on hand.

The fungus goes away quicker… less chance of a re-infection.

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I’m not using Rx Terb. Although my derm MD prescribed that a few years ago. I think it’s too harsh. Many years ago, I had my two BIG toenails removed…ugh… then LOTS OF OTC remedies… I have taken a carvacrol + garlic and something else natural supplement, for systemic help (doing something??) I’m sure the Rapamycin approach should be the BEST, most efficient; but sadly, I don’t have any.
I have stopped getting pedicures the last few months, so I may keep track of appearance, and I know it’s a slow removal. But if it’s systemic also, I might need to deal with this somehow. My diet has been super restricted calories and i eat nothing to which I have been tested for antibodies. I dry my toes.
TMI​:thinking::thinking:
All advice is welcome🙋🏼‍♀️Thank-u bunches.
Sincerely, Jan

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Agetron developed an effective and innovative approach to clear his nails.

As an alternative to terbinafine, fluconazole is reputed to be the safest oral antifungal medication overall. It is sometimes prescribed off label to treat toenail fungus. And it can be pulsed with once per week dosing, making it even safer. It can be used along with a prescription antifungal nail lacquer like Jublia, which has some ability to penetrate the nail.

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I’ll add my anecdote about successfully using iodine to treat toenail fungus. I don’t take rapamycin. If I had had it on hand, I might have tried it first.

In searching for remedies, I came across the same case study that’s linked in message 15 in this thread and was motivated to try it.

To start with, I removed as much as possible of the affected nail. WIth nail clippers I could take off about half of it, the part which had detached from the nail bed. New, healthy growth began almost immediately after I started applying the iodine.

After about two months, at which point about 1/3 of the nail’s length had new, healthy growth, I stopped the iodine.

I also did a course of OTC 1% terbinafine cream towards the end of this time to address occasional itching on the underside of my toes on the same foot. Initially, I’d tried painting that area with iodine, but then became concerned about potentially absorbing an excess of iodine through my skin, and so switched to the terbinafine cream.

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Hi,
My friend used iodine and this helped 100%. I should try this easy approach. Sincerely, thank-u. Jan

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Thanks for this info. Question, when you say dropper squirts do you the full content of the glass part of the drop or a drop?

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A full eye dropper full is a squirt.
Squeeze bulb… load with fluid and squirt…
Repeat! Dropper size…3 inches.

Now 1 year… and 2 and 1/2 months… no fungus!

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