Whenever I see someone add a new compound to their longevity protocol only to end up needing another drug to manage its side effects, I always stop to think about the true risk-benefit balance. In your case (if I understood correctly), rapamycin seems to have required BP medication as a countermeasure. Every molecule we introduce — whether synthetic or natural — has downstream effects on the gut, immune function, and overall aging/health processes. That’s why this matters so much: we’re playing the very long game here. Listen to your body, there’s no one-size-fits-all health protocol for everyone.
Another thought: your post reminded me of a couple of recent case reports linking tirzepatide to DVT. You didn’t mention GLP-1/GIP agonists in your stack (no mention of rapa to your doctor either!), but since you’ve said you’re a bit above your ideal weight, I thought these might be worth flagging just in case you ever consider them:
Hi Raquel, thanks for your response.
To add some nuance I started monitoring my BP when I started taking Rapamycin, I think the conundrum we have with Rapamycin is that it is a powerful drug that has an impact on the body. This is why we take it. So understanding this I have tried to monitor a number of bio markers to see if I have positive or negative responses to the drug. My BP was higher than optimal when I started to monitor and then increased when starting Rapamycin. I like to think this was a positive as after reading lots of posts on this website and doing some research of my own my BP lowering drugs work well with little or no side effects. I will continue them with or without Rapamycin
I have not used GLP-1 drugs to lose weight. I do lots of exercise and eat well… except for late night munchies. Like many middle aged men we can see the problem but struggle with the solution
In my case I have decided to carry on with Rapamycin while I am on my blood thinners but when I stop the blood thinners I will also drop the Rapamycin with the provisio that I will keep an eye open for research papers that may convince me that the risk to reward ratio changes my mind
